Integrative Analysis Reveals Comprehensive Altered Metabolic Genes Linking with Tumor Epigenetics Modification in Pan-Cancer

Table 1

List of the critical different expression genes of categories we studied in the specific types of cancer.

Terms	Genes	Upregulation cancer types	Downregulation cancer types
Methylation	SLC19A1	BRCA/COAD/COADREAD/HNSC/LIHC/STAD	LUAD/LUSC/THCA
	SLC44A4	BRCA/KIRP/LIHC/LUAD	COAD/COADREAD/HNSC/KIRC/LUSC
	DHFR	COAD/COADREAD/HNSC/LUAD/LUSC/STAD
	CHDH	COADREAD/STAD	HNSC/KIRC/LUSC
	BHMT		KIRC/KIRP/LIHC
	MTHFD1	COAD/COADREAD/HNSC/LUAD/LUSC/STAD	LIHC
	MTHFD2	BRCA/COAD/COADREAD/HNSC/KIRC/LIHC/LUAD/LUSC/STAD
	AHCY	BRCA/COAD/COADREAD/LIHC/LUAD/LUSC/STAD	KIRC/KIRP
	MAT1A	BRCA/COAD/COADREAD/LUAD/LUSC	LIHC
	MAT2A	LIHC	THCA
	DNMT1	BRCA/COAD/COADREAD/HNSC/LIHC/LUAD/LUSC/STAD
	DNMT3A	BRCA/HNSC/LIHC/LUAD/LUSC/STAD
	DNMT3B	BRCA/COAD/COADREAD/HNSC/KIRP/LIHC/LUAD/LUSC/STAD
Acetylation	SLC2A1	BRCA/COAD/COADREAD/HNSC/KIRC/LIHC/LUAD/LUSC/STAD
	HK2	HNSC/KIRC/KIRP/LIHC/LUSC/STAD	COAD/COADREAD
	PKM2	BRCA/COAD/COADREAD/HNSC/LIHC/LUAD/LUSC/STAD
	PFKP	BRCA/HNSC/KIRC/KIRP/LUAD/LUSC/STAD
	SLC25A20		BRCA/COAD/COADREAD/HNSC/KIRC/KIRP/LUSC/STAD
	FASN	COAD/COADREAD/LIHC/STAD
	ACACA	COAD/COADREAD/LIHC/STAD	KIRC
	ACLY	COAD/COADREAD/HNSC/KIRC/LIHC
	ACSS2		BRCA/COAD/COADREAD/KIRC/LUSC
	KAT2A	COAD/COADREAD/HNSC/LIHC/LUAD/LUSC/KIRC/KIRP/STAD

Note: the blank content means the genes had no upregulation expression or downregulation in one particular cancer type.