Integrative Analysis Reveals Comprehensive Altered Metabolic Genes Linking with Tumor Epigenetics Modification in Pan-Cancer

Table 2

The different expression genes with hypermethylation or hypomethylation in the specific types of cancer.

Cancer types	Probe	Δβ	Gene	Fold change	value	r	value
BRCA	cg05661282	0.328652	ZNF154	–2.51052	0	–0.5733	4.31E – 69
	cg02938205	0.313603	CCDC36	–4.76933	0	–0.25194	1.03E – 12
	cg11417025	0.340146	SOSTDC1	–3.43449	5.82E – 11	–0.45553	4.54E – 41
	cg17116120	0.203629	COX4I2	–2.06691	0	–0.26144	1.31E – 13
	cg06087421	0.206592	TAL1	–3.82039	0	–0.24326	6.26E – 12
	cg06363129	0.297534	SOSTDC1	–3.43449	5.82E – 11	–0.49109	2.09E – 48
	cg03757145	0.274106	CDKL2	–2.28953	2.5E – 08	–0.63537	4.45E – 89
	cg12042659	0.231631	ZNF132	–2.00658	0	–0.48716	1.49E – 47
	cg07220448	0.29423	SOSTDC1	–3.43449	5.82E – 11	–0.45009	5.08E – 40
	cg10168635	0.267563	C2orf88	–5.55411	0	–0.32566	1.18E – 20
	cg14625175	0.405266	HOXA10	–2.7302	0	–0.2537	7.06E – 13
	cg14263942	0.281991	CDKL2	–2.28953	2.5E – 08	–0.63136	1.19E – 87
	cg18868483	0.301089	B3GAT2	–1.54216	4.51E – 05	–0.22273	3.44E – 10
	cg01454592	0.245132	CCDC36	–4.76933	0	–0.24726	2.75E – 12
	cg10344081	0.294167	CDKL2	–2.28953	2.5E – 08	–0.63967	1.23E – 90
	cg06126713	0.395028	SOSTDC1	–3.43449	5.82E – 11	–0.44907	7.94E – 40
	cg24432073	0.20478	CDKL2	–2.28953	2.5E – 08	–0.62519	1.73E – 85
	cg02085507	0.372686	TRIP10	–1.54805	0	–0.20553	7.39E – 09
	cg05308656	0.253266	ARL4C	–1.64326	6.71E – 13	–0.52274	1.06E – 55
	cg11270393	0.308156	ITPRIPL1	–5.73674	0	–0.39404	2.9E – 30
	cg12506930	0.323833	ZNF154	–2.51052	0	–0.57088	2.14E – 68
	cg07519235	0.459351	GPRC5B	–2.5035	0	–0.49936	3.06E – 50
	cg21113446	0.215296	PPP2R2B	–3.10098	0	–0.33333	1.29E – 21
	cg02324432	0.253122	KLHL2	–1.79165	0	–0.23855	1.62E – 11
	cg04203238	0.274658	PROM1	–1.68571	0.000897	–0.64459	1.9E – 92
	cg04243822	0.216055	C1QTNF1	–3.30512	0	–0.22631	1.76E – 10
	cg00680551	0.424494	NCALD	–3.00007	0	–0.37035	1.14E – 26
	cg27049766	0.32279	ZNF154	–2.51052	0	–0.61756	6.93E – 83
	cg08816590	0.288288	PDE1B	–3.70157	0	–0.30695	2.05E – 18
	cg14988503	0.210715	CDKL2	–2.28953	2.5E – 08	–0.58357	4.19E – 72
	cg18236571	0.263708	PABPC4L	–1.69422	2.54E – 09	–0.48483	4.73E – 47
	cg18085435	–0.20795	ATP8B1	1.700614	8.59E – 08	–0.56131	1.05E – 65
	cg01062470	–0.2649	KIF24	2.804288	0	–0.30429	4.14E – 18
	cg04567302	–0.25404	SLC44A4	5.457885	0	–0.6607	1.26E – 98
	cg16702815	–0.32459	AGR3	5.086635	3.09E – 12	–0.69724	3.7E – 114
	cg10173620	–0.29247	ABHD2	1.920326	0.000667	–0.36501	6.75E – 26
	cg11819637	–0.26298	THPO	3.885221	1.36E – 06	–0.67328	1E – 103
	cg08960448	–0.33095	SEPT12	5.27739	7.67E – 05	–0.30054	1.1E – 17
	cg27530053	–0.20353	FAM83E	3.858755	8.11E – 09	–0.458	1.5E – 41
	cg23631538	–0.3347	DENND2D	1.578295	8.5E – 13	–0.43718	1.31E – 37
	cg12633764	–0.29531	MAPT	1.804312	4.72E – 05	–0.72534	8.3E – 128
KIRC	cg27026192	0.214365	KIFC3	–1.57694	0	–0.36061	2.72E – 11
	cg02993070	0.296156	FERMT2	–1.58269	3.77E – 15	–0.26413	1.59E – 06
	cg02852670	0.260053	KLHL33	–3.21637	0	–0.25921	2.52E – 06
KIRP	cg11800117	0.293577	C11orf75	–1.50718	3.06E – 05	–0.26745	7.16E – 06
	cg20962532	0.209952	KCNJ1	–32.1899	0	–0.26319	1.01E – 05
	cg11968091	0.261459	ODZ4	–2.24539	0.000389	–0.30657	2.26E – 07
	cg05227215	0.41792	CXXC5	–2.04975	0	–0.25958	1.35E – 05
	cg04858586	0.269997	RABGAP1L	–2.15075	5.35E – 13	–0.21864	0.000266
	cg03648711	0.255349	ODZ4	–2.24539	0.000389	–0.2788	2.77E – 06
	cg24277788	0.243307	ACSL1	–2.44389	1.27E – 14	–0.33942	8.17E – 09
	cg03883256	0.265289	USP2	–3.63204	0	–0.21891	0.000261
	cg10416846	0.299733	PNOC	–4.19665	2.27E – 08	–0.25688	1.67E – 05
	cg24127861	0.207238	REC8	–2.2299	0.000653	–0.31031	1.58E – 07
	cg15974053	0.242659	HSD17B14	–2.21561	2.94E – 05	–0.73157	3.69E – 47
	cg16530498	0.222937	HSD17B14	–2.21561	2.94E – 05	–0.74962	1.14E – 50
	cg19414598	0.214085	DMC1	–1.57414	0.010418	–0.46463	4.44E – 16
	cg15731317	–0.37473	SYTL2	1.895209	0.000186	–0.50345	5.16E – 19
	cg00583003	–0.28896	SPP1	2.483728	3.64E – 06	–0.2564	1.73E – 05
	cg21622977	–0.22364	RBPMS	1.793989	3.22E – 08	–0.49531	2.29E – 18
	cg17660833	–0.53805	HRH1	4.616294	2.92E – 08	–0.33817	9.35E – 09
	cg20306842	–0.21944	CREB5	7.099205	1.84E – 10	–0.40814	2.01E – 12
	cg23031196	–0.31756	SLC38A1	1.620018	0.000342	–0.37927	8.38E – 11
	cg01944226	–0.28436	SLC16A3	4.39414	8.6E – 06	–0.76961	6.36E – 55
	cg09182455	–0.41989	CORO1C	2.191563	4E – 11	–0.22222	0.000209
	cg01812894	–0.26035	ALDH1A1	2.206084	0.000791	–0.2834	1.86E – 06
	cg01942558	–0.4858	TNFAIP6	45.14506	1.33E – 05	–0.68008	1.51E – 38
	cg09122223	–0.34216	IL18	2.298725	1.94E – 07	–0.24966	2.91E – 05
	cg16929739	–0.38802	HRH1	4.616294	2.92E – 08	–0.32623	3.25E – 08
	cg09727050	–0.39502	TNFAIP6	45.14506	1.33E – 05	–0.78361	3.61E – 58
	cg07042532	–0.32291	CREB5	7.099205	1.84E – 10	–0.62039	1.54E – 30
	cg13445177	–0.29628	S100A10	1.832289	4.18E – 08	–0.34141	6.61E – 09
	cg14333454	–0.30823	SFN	11.18657	0.034773	–0.7839	3.08E – 58
	cg08778148	–0.2173	TFPI	2.08801	0.00022	–0.44876	5.55E – 15
	cg14578677	–0.23981	TLR6	2.307439	0.007805	–0.44887	5.46E – 15
	cg12669354	–0.35182	CD151	1.854554	1.27E – 11	–0.37366	1.66E – 10
	cg00449608	–0.3179	GPR45	3.093416	0.00448	–0.44012	2.08E – 14
	cg26864526	–0.36952	HRH1	4.616294	2.92E – 08	–0.53238	1.86E – 21
	cg10183885	–0.26987	SLC16A3	4.39414	8.6E – 06	–0.8219	1.96E – 68
	cg06836480	–0.24006	DHRS9	9.536973	0.012336	–0.23825	6.8E – 05
	cg11702866	–0.44443	HRH1	4.616294	2.92E – 08	–0.29902	4.58E – 07
	cg06457736	–0.44623	HRH1	4.616294	2.92E – 08	–0.31287	1.23E – 07
	cg24258705	–0.47246	MET	4.732257	1.75E – 08	–0.63402	3.26E – 32
	cg15717250	–0.34571	UPK1B	4.304701	0.004226	–0.66398	3.33E – 36
	cg03489712	–0.29538	ZYX	1.99858	3.19E – 10	–0.22033	0.000237
	cg09950681	–0.33674	PKP3	2.143401	0.047341	–0.60723	5.34E – 29
	cg14550985	–0.33893	RIN1	5.119397	2.06E – 10	–0.68575	2.09E – 39
	cg21950166	–0.36612	SFN	11.18657	0.034773	–0.71606	2.3E – 44
	cg06720467	–0.34964	SFN	11.18657	0.034773	–0.55134	3.43E – 23
	cg20992002	–0.30043	PKP3	2.143401	0.047341	–0.6543	7.26E – 35
	cg02872476	–0.23267	DBNDD1	3.125374	4.05E – 08	–0.66917	6.07E – 37
LIHC	cg21831174	0.218134	MASP1	–2.16898	0	–0.35207	1.19E – 11
	cg04951797	–0.28077	SGOL1	19.52393	5.5E – 07	–0.62482	2.7E – 39
	cg17336139	–0.25975	PRAME	231.9457	0.018915	–0.36725	1.29E – 12
	cg23213217	–0.24898	DEGS1	2.328115	2.56E – 08	–0.33786	8.59E – 11
	cg11225751	–0.21878	PRAME	231.9457	0.018915	–0.46426	4.12E – 20
	cg06442489	–0.34313	ZSCAN18	1.965757	0.001058	–0.28886	3.75E – 08
	cg20441902	–0.22001	FUT2	14.81239	0.012527	–0.54902	6.06E – 29
	cg25060890	–0.22045	RPS6KC1	2.58206	2.81E – 11	–0.39031	3.5E – 14
	cg03368046	–0.20541	FAM186A	4.276926	0.000748	–0.24311	4.2E – 06
	cg23924737	–0.25896	MRPS23	2.825878	4E – 15	–0.40317	4.11E – 15
	cg01999046	–0.30348	TRAF2	3.59974	4E – 15	–0.48642	3.45E – 22
	cg03212674	–0.22852	CLK2	3.219276	7.32E – 13	–0.26115	7.25E – 07
	cg02516101	–0.21135	CSNK1E	2.573716	5E – 09	–0.43473	1.44E – 17
	cg07303143	–0.37162	KIAA1143	1.713539	2.33E – 07	–0.4433	2.79E – 18
LUAD	cg04372674	0.214314	AQP1	–2.70913	7.09E – 14	–0.6127	3.66E – 49
	cg25075794	0.226309	AQP1	–2.70913	7.09E – 14	–0.60885	2.09E – 48
	cg02571816	0.216135	PPP1R14A	–3.40955	0	–0.34411	2.41E – 14