Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis

Table 1

Characteristics of the studies included in the meta-analysis.

First author	Year	Diagnosis	Country	Cases			Control			TLR4 polymorphisms	NOS score
				No.	Age	F/M	No.	Age	F/M
Shibuya et al.	2008	NTG	Japan	250	46.1 ± 7.7	131/119	318	61.2 ± 8.3	161/157	rs10759930, rs1927914, rs1927911, rs12377632, rs2149356, rs11536889, rs7037117, rs7045953	7
Suh et al.	2011	NTG	Korea	147	NA	NA	380	NA	NA	rs10759930, rs1927914, rs1927911, rs12377632, rs2149356, rs11536889, rs7037117, rs7045953	7
Takano et al.	2012	NTG	Japan	365	58.6 ± 13.1	194/171	216	69.7 ± 11.3	100/116	rs10759930, rs1927914, rs1927911, rs12377632, rs2149356, rs11536889, rs7037117, rs7045953	7
		POAG		184	64.6 ± 14.3	65/119	216	69.7 ± 11.3	100/116
Chen et al.	2012	POAG	China (Hong Kong)	184	59.7 ± 16.6	64/120	230	73.5 ± 7.5	124/106	rs7037117	7
			China (Shantou)	102	45.2 ± 20.8	20/82	147	74.0 ± 6.4	94/53
			China (Beijing)	176	38.9 ± 16.3	38/138	200	69.4 ± 6.0	50/150
Mousa et al.	2016	POAG	Saudi Arabia	85	60.9 ± 12.7	32/53	95	58.7 ± 10.4	38/57	rs4986791	8
Abu-Amero et al.	2017	POAG	Saudi Arabia	85	60.9 ± 12.7	32/53	95	58.7 ± 10.4	38/57	rs4986790	8
Navarro-Partida et al.	2017	POAG	Mexico	187	66.49 ± 14.3	95/94	109	63.28 ± 7.93	69/40	rs4986790, rs4986791	8
Navarro-Partida et al.	2017	POAG	Mexico	187	66.49 ± 14.3	95/94	109	63.28 ± 7.93	69/40	rs1927911, rs12377632, rs2149356, rs11536889	8

NTG= normal tension glaucoma, POAG= primary open angle glaucoma, No.=number, F/M=female/male, and NOS= Newcastle-Ottawa Scale; NA=not applicable.