Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis
Table 2
Meta-analysis of the association between TLR4 polymorphisms and OAG.
SNP
Variables
No. of studies
Allelic model (2 vs. 1)
Dominant model (22+12 vs. 11)
Recessive model (22 vs. 12+11)
OR (95%CI)
P
I2 (%)
OR (95%CI)
P
I2 (%)
OR (95%CI)
P
I2 (%)
rs7037117
Total
5
1.25 (1.09,1.44)
0.002
46
1.26 (0.94,1.69)
0.12
66
1.49 (1.08,2.04)
0.01
4
Diagnosis
POAG
2
1.19 (0.83,1.70)
0.34
53
1.15 (0.60,2.19)
0.68
80
1.71 (1.10,2.66)
0.02
40
NTG
3
1.27 (0.97,1.68)
0.09
61
1.34 (0.93,1.92)
0.11
66
1.28 (0.82,2.01)
0.28
0
rs10759930
Total
4
1.31 (1.04,1.65)
0.02
68
1.50 (1.04,2.19)
0.03
75
1.29 (1.01,1.66)
0.04
0
Diagnosis
POAG
1
1.71 (1.29,2.29)
0.0002
NA
2.51 (1.65,3.83)
<0.0001
NA
1.41 (0.82,2.45)
0.22
NA
NTG
3
1.21 (0.96,1.53)
0.11
61
1.29 (0.94,1.78)
0.11
58
1.26 (0.95,1.67)
0.10
0
rs1927914
Total
4
1.15 (0.70,1.88)
0.59
93
1.08 (0.42,2.75)
0.88
95
1.15 (0.90,1.47)
0.28
49
Diagnosis
POAG
1
1.75 (1.31,2.34)
0.0001
NA
2.76 (1.80,4.22)
<0.0001
NA
1.31 (0.75,2.26)
0.34
NA
NTG
3
1.00 (0.55,1.82)
0.99
94
0.78 (0.25,2.49)
0.68
96
1.09 (0.68,1.76)
0.71
65
rs7045953
Total
4
1.19 (0.94,1.50)
0.15
13
1.19 (0.93,1.53)
0.16
14
1.39 (0.49,3.94)
0.54
0
Diagnosis
POAG
1
1.54 (0.90,2.62)
0.11
NA
1.61 (0.91,2.83)
0.10
NA
1.17 (0.07,18.92)
0.91
NA
NTG
3
1.12 (0.86,1.45)
0.41
15
1.11 (0.84,1.47)
0.47
7
1.43 (0.46,4.39)
0.54
0
rs1927911
Total
5
1.20 (0.92,1.58)
0.18
77
1.21 (0.75,1.96)
0.44
86
1.34 (1.06,1.71)
0.02
0
Ethnicity
Asian
4
1.33 (1.04,1.69)
0.02
70
1.52 (1.05,2.20)
0.03
75
1.31 (1.02,1.69)
0.04
0
Mexican
1
0.69 (0.43,1.08)
0.10
NA
0.41 (0.23,0.74)
0.003
NA
1.68 (0.75,3.79)
0.21
NA
Diagnosis
POAG
2
1.13 (0.44,2.88)
0.80
92
1.03 (0.17,6.07)
0.97
96
1.63 (1.03,2.59)
0.04
0
NTG
3
1.22 (0.97,1.53)
0.10
59
1.31 (0.95,1.80)
0.10
58
1.25 (0.94,1.66)
0.12
0
rs12377632
Total
5
1.33 (1.06,1.67)
0.01
70
1.53 (1.11,2.09)
0.009
67
1.32 (1.05,1.66)
0.02
46
Ethnicity
Asian
4
1.30 (0.99,1.71)
0.06
76
1.46 (1.02,2.10)
0.04
74
1.27 (0.86,1.88)
0.23
57
Mexican
1
1.50 (1.07,2.10)
0.02
NA
1.95 (1.07,3.54)
0.03
NA
1.54 (0.92,2.57)
0.10
NA
Diagnosis
POAG
2
1.71 (1.37,2.14)
<0.001
3
2.18 (1.55,3.06)
<0.001
0
1.82 (1.25,2.63)
0.002
0
NTG
3
1.16 (0.93,1.44)
0.18
54
1.28 (0.90,1.81)
0.17
65
1.08 (0.81,1.45)
0.59
0
rs2149356
Total
5
1.41 (1.12,1.78)
0.004
71
1.65 (1.15,2.36)
0.006
76
1.38 (1.09,1.75)
0.009
0
Ethnicity
Asian
4
1.34 (1.04,1.73)
0.02
74
1.49 (1.02,2.18)
0.04
76
1.39 (1.08,1.79)
0.01
0
Mexican
1
1.80 (1.26,2.59)
0.001
NA
2.63 (1.61,4.27)
<0.001
NA
1.31 (0.63,2.71)
0.47
NA
Diagnosis
POAG
2
1.81 (1.44,2.26)
<0.001
0
2.51 (1.83,3.44)
<0.001
0
1.56 (1.00,2.45)
0.05
0
NTG
3
1.22 (0.94,1.59)
0.13
67
1.29 (0.91,1.83)
0.16
65
1.31 (0.99,1.74)
0.06
2
rs11536889
Total
5
1.05 (0.91,1.20)
0.53
0
1.13 (0.95,1.34)
0.17
0
0.77 (0.52,1.13)
0.18
0
Ethnicity
Asian
4
1.06 (0.92,1.23)
0.41
1
1.15 (0.96,1.37)
0.13
3
0.81 (0.55,1.20)
0.29
0
Mexican
1
0.86 (0.52,1.43)
0.56
NA
0.94 (0.54,1.66)
0.84
NA
0.19 (0.02,1.85)
0.15
NA
Diagnosis
POAG
2
1.04 (0.79,1.37)
0.76
0
1.19 (0.86,1.65)
0.29
0
0.44 (0.18,1.09)
0.08
0
NTG
3
1.05 (0.89,1.23)
0.58
31
1.10 (0.90,1.35)
0.34
16
0.88 (0.57,1.36)
0.57
0
OR: odds ratio; 95%CI: 95% confidence interval; POAG: primary open angle glaucoma; NTG: normal tension glaucoma; NA: not applicable. The involved studies for these polymorphisms only included Asian populations; thus the overall results also represented the results in Asian subgroup.
