Cooccurrence of NDM-1, ESBL, RmtC, AAC(6′)-Ib, and QnrB in Clonally Related Klebsiella pneumoniae Isolates Together with Coexistence of CMY-4 and AAC(6′)-Ib in Enterobacter cloacae Isolates from Saudi Arabia
Table 2
Antimicrobial resistance profile of six resistant Klebsiella pneumoniae and Enterobacter cloacae isolates.
Antibiotics
MIC (mg/L)
KP-Q1
KP-Q2
KP-Q3
KP-Q4
EN.C.Q5
EN.C.Q6
Amoxicillin
>256
>256
>256
>256
>256
>256
Piperacillin
>256
>256
>256
>256
>256
>256
Ticarcillin
>256
>256
>256
>256
>256
>256
Cefoperazone
>256
>256
>256
>256
>256
>256
Cefotaxime
>256
>256
>256
>256
>256
>256
Ceftazidime
>256
>256
>256
>256
>256
>256
Cefepime
>256
>256
>256
>256
>256
>256
Aztreonam
>256
>256
>256
>256
>256
>256
Cefoxitin
>256
>256
>256
>256
>256
>256
Cefotetan
>256
>256
>256
>256
>256
>256
Imipenem
>256
>256
>256
>256
>256
>256
Meropenem
>32
>32
>32
>32
>32
>32
Doripenem
>32
>32
>32
>32
>32
>32
Amikacin
>256
>256
>256
>256
24 (S)
>256
Gentamicin
>256
>256
>256
>256
64
>256
Nalidixic acid
>256
>256
>256
>256
>256
>256
Ciprofloxacin
>32
>32
>32
>32
2 (S)
8
Ofloxacin
>32
>32
>32
>32
2 (S)
8
Tigecycline
0.75
0.75
0.75
0.19 (S)
2
2
Colistin
0.75 (S)
3
1.5 (S)
2 (S)
0.75 (S)
0.75 (S)
Inhibition zone diameter (mm) by disk diffusion
Sulfamethoxazole/trimethoprim 23.75 / 1.25 µg
6
6
6
6
6
6
Tetracycline 30 μg
6
6
8
15 (S)
6
12 (I)
Chloramphenicol 30 μg
22 (S)
23 (S)
21 (S)
16 (S)
6
6
KP: Klebsiella pneumoniae, EN.C: Enterobacter cloacae S: susceptible, I: intermediate Disk diameter is 6 mm MIC: Minimum Inhibitory Concentration Resistance interpretation for all antimicrobials unless labeled S or I Interpretation according to CLSI guidelines (2016) except for tigecycline and colistin, which were interpreted according to EUCAST guidelines (2019).
