Cooccurrence of NDM-1, ESBL, RmtC, AAC(6′)-Ib, and QnrB in Clonally Related Klebsiella pneumoniae Isolates Together with Coexistence of CMY-4 and AAC(6′)-Ib in Enterobacter cloacae Isolates from Saudi Arabia

Table 3

Antibiotic resistance enzymes and genotypic screening of six resistant Klebsiella pneumonia and Enterobacter cloacae isolates.

Strain	Carbapenemase	Size of plasmids harboring carbapenemase-encoding genes	ESBL	BSBL	16S rRNA methylase	AmpC variant	Aminoglycoside-modifying enzyme (acetyltransferase)	Quinolone resistance enzymes	MLST
KP-Q1	NDM-1	70 kb	CTX-M-3	TEM-1, OXA-1	RmtC	-	AAC(6′)-Ib	QnrB	ST152
KP-Q2	NDM-1	70 kb	CTX-M-57	TEM-1, OXA-1	RmtC	-	AAC(6′)-Ib	QnrB	ST152
KP-Q3	NDM-1	70 kb	CTX-M-82	TEM-1, OXA-1	RmtC	-	AAC(6′)-Ib	QnrB	ST152
KP-Q4	NDM-1	70 kb	CTX-M-15	TEM-1, OXA-1	-	-	AAC(6′)-Ib	-	ST572
EN.C.Q5	VIM-1	60 kb	-	TEM-1	-	CMY-4	-	-	ST171
EN.C.Q6	VIM-1	150 kb	-	-	-	-	AAC(6′)-Ib	-	ST73

KP: Klebsiella pneumoniae
EN.C: Enterobacter cloacae
ESBL: Extended-spectrum β-lactamase
MLST: Multilocus sequence typing