Drug-Loaded Microbubbles Combined with Ultrasound for Thrombolysis and Malignant Tumor Therapy

Table 1

The combination of drug-loaded microbubbles and ultrasound for tumor treatment.

Drug	Type of microbubble	Microbubble size	Type of tumor	Application	Ref.
Doxorubicin	Lipid MB	4.00 μm	Malignant glioma	Exploring the inhibition ratio to human glioblastoma cells	[68]
Carmustine	Lipid MB	1.32 μm	Glioblastoma multiforme	Investigating the treatment efficacy in rat glioma model	[69]
Doxorubicin	Lipid MB	1.04 μm	Glioblastoma multiforme	Investigating the efficiency of opening BBB and drug delivery	[70]
Docetaxel	Lipid MB	623.10 nm	Liver tumor	Inhibiting tumor growth in a rabbit liver tumor model	[30]
Hydroxycamptothecin	Lipid MB	1.48 μm	Liver tumor	Increasing the rate of tumor inhibition	[71]
Doxorubicin	Poly(lactic acid) MB	1.50 μm	Liver tumor	Achieving the treatment in rabbit liver tumor model	[72]
Doxorubicin	Lipid MB	1.02 μm	Pancreas carcinoma	Achieving the treatment of pancreatic cancer in rat model	[31]
Docetaxel	Lipid MB	3.30 μm	Colon adenocarcinoma	Investigating the antitumor effect on human colon adenocarcinoma cell line	[73]
Paclitaxel	Lipid MB	1.68 μm	Breast cancer	Achieving the treatment in mice breast cancer model	[74]
Doxorubicin	Lipid MB	1.64 μm	Breast cancer	Investigating the antitumor effect on human breast cancer cells	[75]
Paclitaxel	Lipid MB	1.80 μm	Ovarian cancer	Investigating the antitumor effect on human ovarian carcinoma cells	[76]
Paclitaxel	Lipid MB	1.80 μm	Ovarian cancer	Achieving the treatment of in mice ovarian cancer model	[77]