Minocycline Protects against Rotenone-Induced Neurotoxicity Correlating with Upregulation of Nurr1 in a Parkinson’s Disease Rat Model

Figure 4

Expression of the total-cAMP-response element binding protein (t-CREB) and phosphorylated-cAMP-response element binding protein (p-CREB) in the SN of rats. (a) The protein expression of t-CREB and p-CREB in the SN of rats (n=5 for each group) determined by western blot analysis. (b) Ratio of p-CREB/t-CREB in the SN of rats. Significantly decreased p-CREB/t-CREB ratio was observed in the SN of rats exposed to rotenone compared to the control group, whereas it was higher in the minocycline-plus-rotenone group compared to the rotenone group. <0.05, compared to the control group; ^#p<0.05, compared to the rotenone-alone group.

(a)

(b)