Elevated Preoperative Serum CA125 Predicts Larger Tumor Diameter in Patients with Hepatocellular Carcinoma and Low AFP Levels
Table 2
Comparison of clinicopathological characteristics between two groups stratified by CA125 level (n = 427).
Characteristics
CA125 ≤30 U/mL (n = 392)
CA125 >30 U/mL (n = 35)
Age (years) (≤65/>65)
325/67
31/4
0.389
Gender (male/female)
340/52
26/9
0.044
Cirrhosis (yes/No)
335/57
31/4
0.614
Virus hepatitis (HBV/HCV/non-HBV, non-HCV)
332/8/52
27/0/8
0.184
Child-Pugh (A/B)
383/9
32/3
0.074
ALT (U/L) (≤60/>60)
323/69
30/5
0.619
T-Bil (Umol/L) (≤20/>20)
304/88
26/9
0.659
Anatomical resection (yes/no)
130/262
16/19
0.134
Surgical margin (mm) (≤10/>10)
335/57
29/6
0.677
MTD (cm) (≤5/>5)
307/85
13/22
<0.001
Number of nodules (1/>1)
332/60
31/4
0.538
Microvascular invasion (yes/no)
82/310
9/26
0.507
Differentiation (well/mod, poor)
48/344
2/33
0.381
TNM stage
I
304
24
0.115
II
56
4
III
32
7
HBV, viral hepatitis B; HCV, viral hepatitis C; ALT, alanine transaminase; T-Bil, total bilirubin; MTD, maximal tumor diameter; IQR, interquartile range. TNM stages were assigned according to the criteria described in the AJCC Cancer Staging Manual (8th Edition).
