Elevated Preoperative Serum CA125 Predicts Larger Tumor Diameter in Patients with Hepatocellular Carcinoma and Low AFP Levels
Table 3
Univariate and multivariate analyses of DFS in the entire patients (n = 427).
Clinicopathological parameters
Univariate analysis
Multivariate analysis
HR (95% CI)
HR (95% CI)
Age (years) (≤65/>65)
1.078 (0.757–1.536)
0.676
Gender (male/female)
0.685 (0.448–1.047)
0.080
Cirrhosis (yes/no)
1.596 (1.017–2.506)
0.042
1.708 (1.079–2.703)
0.022
Virus hepatitis (HBV/HCV/non-HBV, non-HCV)
0.954 (0.834–1.091)
0.489
Child-Pugh (A/B)
6.454 (3.366–12.374)
<0.001
6.373 (3.289–12.349)
<0.001
ALT (U/L) (≤60/>60)
1.237 (0.886–1.726)
0.212
T-Bil (Umol/L) (≤20/>20)
0.973 (0.678–1.397)
0.884
CA125 (U/mL) (≤30/>30)
1.913 (1.241–2.950)
0.003
Anatomical resection (yes/no)
0.788 (0.591–1.050)
0.104
Surgical margin (mm) (≤10/>10)
0.706 (0.472–1.056)
0.090
MTD (cm) (≤5/>5)
2.085 (1.574–2.763)
<0.001
1.891 (1.379–2.592)
<0.001
Number of nodules (1/>1)
2.092 (1.509–2.899)
<0.001
Microvascular invasion (yes/no)
1.536 (1.122–2.102)
0.007
Differentiation (well/mod, poor)
1.175 (0.769–1.796)
0.455
TNM stage(I/II/III)
1.808 (1.504–2.147)
<0.001
1.358 (1.052–1.753)
0.019
HBV, viral hepatitis B; HCV, viral hepatitis C; ALT, alanine transaminase; T-Bil, total bilirubin; MTD, maximal tumor diameter; IQR, interquartile range. TNM stages were assigned according to the criteria described in the AJCC Cancer Staging Manual (8th Edition).
