BioMed Research International / 2019 / Article / Tab 3

Clinical Study

Elevated Preoperative Serum CA125 Predicts Larger Tumor Diameter in Patients with Hepatocellular Carcinoma and Low AFP Levels

Table 3

Univariate and multivariate analyses of DFS in the entire patients (n = 427).

Clinicopathological parametersUnivariate analysisMultivariate analysis
HR (95% CI)HR (95% CI)

Age (years) (≤65/>65)1.078 (0.757–1.536)0.676
Gender (male/female)0.685 (0.448–1.047)0.080
Cirrhosis (yes/no)1.596 (1.017–2.506)0.0421.708 (1.079–2.703)0.022
Virus hepatitis (HBV/HCV/non-HBV, non-HCV)0.954 (0.834–1.091)0.489
Child-Pugh (A/B)6.454 (3.366–12.374)<0.0016.373 (3.289–12.349)<0.001
ALT (U/L) (≤60/>60)1.237 (0.886–1.726)0.212
T-Bil (Umol/L) (≤20/>20)0.973 (0.678–1.397)0.884
CA125 (U/mL) (≤30/>30)1.913 (1.241–2.950)0.003
Anatomical resection (yes/no)0.788 (0.591–1.050)0.104
Surgical margin (mm) (≤10/>10)0.706 (0.472–1.056)0.090
MTD (cm) (≤5/>5)2.085 (1.574–2.763)<0.0011.891 (1.379–2.592)<0.001
Number of nodules (1/>1)2.092 (1.509–2.899)<0.001
Microvascular invasion (yes/no)1.536 (1.122–2.102)0.007
Differentiation (well/mod, poor)1.175 (0.769–1.796)0.455
TNM stage(I/II/III)1.808 (1.504–2.147)<0.0011.358 (1.052–1.753)0.019

HBV, viral hepatitis B; HCV, viral hepatitis C; ALT, alanine transaminase; T-Bil, total bilirubin; MTD, maximal tumor diameter; IQR, interquartile range. TNM stages were assigned according to the criteria described in the AJCC Cancer Staging Manual (8th Edition).

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