BioMed Research International / 2019 / Article / Tab 4

Clinical Study

Elevated Preoperative Serum CA125 Predicts Larger Tumor Diameter in Patients with Hepatocellular Carcinoma and Low AFP Levels

Table 4

Univariate and multivariate analyses of OS in the entire patients (n = 427).

Clinicopathological parametersUnivariate analysisMultivariate analysis
HR (95% CI)HR (95% CI)

Age (years) (≤65/>65)1.034 (0.655–1.632)0.887
Gender (male/female)0.865 (0.513–1.458)0.586
Cirrhosis (yes/no)2.313 (1.313–4.732)0.0222.615 (1.266–5.401)0.009
Virus hepatitis (HBV/HCV/non-HBV, non-HCV)1.036 (0.877–1.224)0.679
Child-Pugh (A/B)5.782 (3.013–11.099)<0.0014.942 (2.395–10.198)<0.001
ALT (U/L) (≤60/>60)1.562 (1.050–2.323)0.028
T-Bil (Umol/L) (≤20/>20)0.687 (0.413–1.142)0.147
CA125 (U/mL) (≤30/>30)2.266 (1.361–3.771)0.002
Anatomical resection (yes/no)0.746 (0.513–1.086)0.127
Surgical margin (mm) (≤10/>10)0.498 (0.275–0.901)0.021
MTD (cm) (≤5/>5)3.013 (2.140–4.243)<0.0012.709 (1.848–3.972)<0.001
Number of nodules (1/>1)2.064 (1.381–3.087)<0.001
Microvascular invasion (yes/no)1.583 (1.063–2.358)0.024
Differentiation (well/mod, poor)1.357 (0.766–2.404)0.296
TNM stage (I/II/III)2.175 (1.745–2.712)<0.0011.471 (1.109–1.951)0.007

HBV: viral hepatitis B; HCV, viral hepatitis C; ALT, alanine transaminase; T-Bil, total bilirubin; MTD, maximal tumor diameter; IQR, interquartile range. TNM stages were assigned according to the criteria described in the AJCC Cancer Staging Manual (8th Edition).

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