Elevated Preoperative Serum CA125 Predicts Larger Tumor Diameter in Patients with Hepatocellular Carcinoma and Low AFP Levels
Table 4
Univariate and multivariate analyses of OS in the entire patients (n = 427).
Clinicopathological parameters
Univariate analysis
Multivariate analysis
HR (95% CI)
HR (95% CI)
Age (years) (≤65/>65)
1.034 (0.655–1.632)
0.887
Gender (male/female)
0.865 (0.513–1.458)
0.586
Cirrhosis (yes/no)
2.313 (1.313–4.732)
0.022
2.615 (1.266–5.401)
0.009
Virus hepatitis (HBV/HCV/non-HBV, non-HCV)
1.036 (0.877–1.224)
0.679
Child-Pugh (A/B)
5.782 (3.013–11.099)
<0.001
4.942 (2.395–10.198)
<0.001
ALT (U/L) (≤60/>60)
1.562 (1.050–2.323)
0.028
T-Bil (Umol/L) (≤20/>20)
0.687 (0.413–1.142)
0.147
CA125 (U/mL) (≤30/>30)
2.266 (1.361–3.771)
0.002
Anatomical resection (yes/no)
0.746 (0.513–1.086)
0.127
Surgical margin (mm) (≤10/>10)
0.498 (0.275–0.901)
0.021
MTD (cm) (≤5/>5)
3.013 (2.140–4.243)
<0.001
2.709 (1.848–3.972)
<0.001
Number of nodules (1/>1)
2.064 (1.381–3.087)
<0.001
Microvascular invasion (yes/no)
1.583 (1.063–2.358)
0.024
Differentiation (well/mod, poor)
1.357 (0.766–2.404)
0.296
TNM stage (I/II/III)
2.175 (1.745–2.712)
<0.001
1.471 (1.109–1.951)
0.007
HBV: viral hepatitis B; HCV, viral hepatitis C; ALT, alanine transaminase; T-Bil, total bilirubin; MTD, maximal tumor diameter; IQR, interquartile range. TNM stages were assigned according to the criteria described in the AJCC Cancer Staging Manual (8th Edition).
