Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2019, Article ID 6970890, 7 pages
https://doi.org/10.1155/2019/6970890
Research Article

Association of Serum PSP/REG I with Renal Function in Pregnant Women

1Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China
2Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Rämistrasse 10, Zurich 8091, Switzerland
3Department of Clinical Science and Research, Zhongda Hospital, Southeast University, Nanjing 210009, China

Correspondence should be addressed to Rolf Graf; hc.zsu@farg.flor and Ling Li; moc.621@gnilil_rd

Received 27 December 2018; Revised 16 March 2019; Accepted 3 April 2019; Published 21 April 2019

Academic Editor: Toshiyuki Sawaguchi

Copyright © 2019 Xiangyun Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pancreatic stone protein/regenerating protein Iα (PSP/REG Iα) is a secretory protein produced in the pancreas, but its expression has also been observed in the kidney. It may be associated with kidney dysfunction. This study investigates the possible association between PSP/REG Iα and kidney function in pregnant women. Serum PSP/REG Iα levels were measured by a specific ELISA enzyme-linked immunosorbent assay. Maternal information and clinical and biochemical parameters were collected. Estimated glomerular filtration rate (eGFR) was calculated for all individuals to evaluate their renal function. Spearman’s correlation and multiple linear regression analyses were performed to assess the associations between PSP/REG Iα and eGFR, serum creatinine (Cr), blood urea nitrogen (BUN), and uric acid (UA). A total of 595 pregnant women were enrolled in the study. Participants with mildly reduced eGFR had higher PSP/REG Iα levels [50.49 (35.02, 58.64)] than in the general population [26.84 (21.02, 33.07)] (p < 0.001). Included participants were stratified into PSP/REG Iα quartiles; significant differences were observed in the levels of eGFR, serum Cr, BUN, and UA. PSP/REG Iα was negatively correlated with eGFR (r = −0.402, p < 0.001) and positively associated with serum Cr (r = 0.468, p < 0.001), BUN (r = 0.166, p < 0.001), and UA (r = 0.207, p < 0.001). The linear regression analysis indicated that PSP/REG Iα was associated with UA, BUN, and eGFR. High PSP/REG Iα concentrations were closely associated with renal dysfunction in pregnant women. Our study provides clinical evidence that serum PSP/REG Iα levels could be a novel biomarker for assessment of renal function in pregnant women.