Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain

Figure 6

Effects of pulp exposure on mechanical hypersensitivity. The Nav1.7 in TG from the sham, pulpitis rats, and rats with pulpitis given PF04856264 (an Nav1.7 antagonist, 30 mg/kg) on postoperative day 14. PF04856264 significantly increased the facial mechanical pain threshold in the pulpitis rats (n=8, p<0.01). When PF04856264 was administered, the increase in threshold started at 0 h after and reached a maximum at 1h after injection.