Therapeutic Effect of Dunaliella salina Microalgae on Thioacetamide- (TAA-) Induced Hepatic Liver Fibrosis in Rats: Role of TGF-β and MMP9

Figure 3

(a) Liver of control normal rat showing the normal histological structure of hepatic lobule (stage F0). (b) Liver of rat from the TAA group showing ballooning degeneration of hepatocytes (small arrow), fibrosis of hepatocytes (large arrow), and mononuclear cells infiltration (arrow head) (stage F3). (c) Liver of rat from TAA group showing portal fibrosis (small arrow) with oval cells proliferation (large arrow) (stage F3). (d) Liver of rat from silymarin-treated group showing fine strands of fibroblasts in portal tract (arrow) (stage F1). (e) Liver of rat from D. salina (100 mg/kg) showing fatty change of hepatocytes (small arrow) and portal infiltration with inflammatory cells (large arrow) (stage F1). (f) Liver of rat from D. salina (200 mg/kg) showing slight hydropic degeneration of hepatocytes (small arrow) and portal infiltration with inflammatory cells (large arrow) (stage F1) (H&E, ×400).

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