Review Article
Long Noncoding RNAs in Pathological Cardiac Remodeling: A Review of the Update Literature
Table 2
LncRNAs involved in myocardial remodeling.
| Type | Cellular behavior | LncRNAs | Regulation | Target genes | Related functions | References |
| Post-ischemia/hypoxia myocardial remodelling | Autophagy | Neat1 | | Foxo1 | activate autophagy, aggravate CM injury | Ma et al. [49] | AK139328 | | miR-204-3p | activate autophagy, aggravate CM injury | Yu et al. [50] | APF | | miR-188-3p | induce autophagic cell death | Wang et al. [51] | CAIF | | p53 | inhibit autophagy | Liu et al. [52] | AK088388 | | miR-30a | induce autophagic injury | Wang et al. [53] |
| Post-ischemia/hypoxia myocardial remodelling | Apoptosis | CARL | | miR-539 | suppress mitochondrial fission and apoptosis | Wang et al. [54] | MALAT1 | | miR-203 | exacerbate inflammation and apoptosis | Wang et al. [55] | HOTAIR | | miR-125, miR-1 | inhibit apoptosis | Li et al. [56] Gao et al. [57] | UCA1 | | unspecified | suppress ER-stress and apoptosis | Chen et al. [58] | XIST | | miR-130a-3p | facilitate apoptosis, inhibit proliferation | Zhou et al. [59] |
| Post-ischemia/hypoxia myocardial remodelling | Necrosis | NRF | | miR-873 | facilitate necrosis | Wang et al. [60] | H19 | | miR-103/107 | promote necrosis | Wang et al. [61] |
| Myocardial hypertrophy | Hypertrophy | Mhrt | | Brg1 | inhibit cardiac hypertrophy | Hang et al. [62] Han et al. [63] | Chast | | Plekhm1 | hinder autophagy and facilitate hypertrophy | Viereck et al. [64] | CHRF | | miR-489 | anti-hypertrophic | Wang et al. [65] | ROR | | miR-133 | promote hypertrophy | Jiang et al. [66] | H19 | | miR-675 | protect CMs from hypertrophy | Liu et al. [67] | Plscr4 | | miR-214 | attenuate cardiac hypertrophy | Lv et al. [68] | MIAT | | miR-150 | promote hypertrophy | Zhu et al. [69] |
| Myocardial hypertrophy | Electrical remodeling | TCONS_00075467 | | miRNA-328 | affect the effective refractory period, increase the action potential duration in AF | Li et al. [70] | MALAT1 | | miR-200c | regulate transient outward potassium current | Zhu et al. [71] |
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Neat1: nuclear-enriched abundant transcript1; APF: autophagy promoting factor; CAIF: cardiac autophagy inhibitory factor; CARL: cardiac apoptosis-related lncRNA; MALAT1:metastasis-associated lung adenocarcinoma transcript 1; HOTAIR:HOX antisense intergenic RNA;UCA1:urothelial carcinoma-associated; XIST:X-inactive specific transcript; Mhrt: myosin heavy chain associated RNA transcripts; Chast: cardiac hypertrophy-associated transcript; Plekhm1:pleckstrin homology domain-containing protein family M member 1; CHRF: cardiac hypertrophy-related factor; MIAT: myocardial infarction–associated transcript; Foxo1:forkhead box protein O1;ER:endoplasmic reticulum; CM: cardiomyocyte; AF: atrial fibrillation.
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