First Description of Macrolide-Resistant Mycoplasma pneumoniae in Adults with Community-Acquired Pneumonia in Italy

Table 1

Findings of the 15 patients living in the Puglia region of Italy whose swab, sputum, or BAL samples were positive for M. pneumoniae in January 2013 to April 2015.

Patient no.	Age, years (sex)	Sample type	Hospitalized	Susceptibility to macrolides (SNP)	MLVA type	MLVA profile	P1 gene type
1	65 (F)	BAL	yes	wt	-	-	1
2	80 (M)	sputum	no	wt	-	-	2
3	87 (F)	sputum	no	wt	-	-	-
4	44 (M)	BAL	yes	wt	J	(3/4/5/7/2)	1
5	32 (M)	NPS	no	R (A2063G)	NC	(3/0/6/6/2)	2
6	62 (M)	NPS	no	wt	NC	(0/0/5/6/2)	2
7	61 (F)	NPS	no	wt	A	(1/4/5/7/2)	1
8	20 (M)	sputum	yes	wt	NC	(5/0/5/6/2)	2
9	49 (M)	NPS	no	wt	NC	(7/0/6/5/2)	2
10	37 (F)	BAL	yes	R (A2063G)	Z	(7/4/5/7/2)	1
11	37 (F)	NPS	no	wt	-	-	1
12	18 (M)	NPS	yes	wt	-	-	1
13	52 (M)	NPS	no	wt	-	-	2
14	23 (F)	sputum	no	wt	NC	(3/0/6/7/2)	1
15	31 (F)	NPS	no	R (A2064G)	-	-	2

Bronchoalveolar Lavage.
Nasopharyngeal swab.
Not classifiable using the scheme proposed by Degrangè et al. (2009).
MLVA: multiple-locus variable-number tandem repeat analysis; R: resistant; SNP: single nucleotide polymorphism; wt: wild type.