IGHG1 Regulates Prostate Cancer Growth via the MEK/ERK/c-Myc Pathway

Figure 5

IGHG1 functions via the MEK/ERK/c-Myc axis to regulate PCa tumor growth in vivo. (a) DU145 cells were injected to nude mice, together with or without IGHG1 genetic silenced or IGHG1 antibody injection. One month later, mice were sacrificed, and the tumors were isolated. (b) The tumor weight was evaluated, and the samples lysates were subjected to western blot to detect the activation of MEK/ERK pathway ((c) and (d)) and the expression of c-Myc protein ((e) and (f)). Data are expressed as the mean ± SD. denotes p < 0.05.

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