(a) Characteristics of the included studies |
| | First Author (Year of Publication) | Study Design | Study Location | Population (Mean age) | Female/
Male | Intervention |
| | Nizam N (2018) | RCT, SM | School of Dentistry, Ege University, İzmir, Turkey | Thirteen patients
(mean age ± SD: 49.92 ± 10.37) | 4/9 | Bio-Oss and L-PRF mixture (test)
Bio-Oss alone (control) |
| Zhang Y
(2012) | RCT, P | Department of Implant Dentistry, Peking University,
School and Hospital of Stomatology, Beijing, China | The test group: six sinuses from six patients (mean age, 43.5 years; range, 30-49)
the control group: five sinuses of five patients (mean age, 46.2 years; range, 37-53). | 2/8 | Bio-Oss and L-PRF mixture (test)
Bio-Oss alone (control) |
| | Comert K S, 2017 | RCT, P | Department of Oral and Maxillofacial Surgery, Center for Oral and Dental Health, Erzurum, Turkey | 26 patients: Ages ranged from 22-51 years
The control group: 31.51±8.52 years
The P-PRP group: 34.01±9.59 years
The PRF group: 35.48±9.53 years | 9 /17 | B-TCP (control);
P-PRP mixed B-TCP (The P-PRP group);
PRF mixed B-TCP (PRF group). |
| Tatullo M,
2012 | RCT, P | Dept. of Basic Medical Science, University of Bari, Italy | 60 patients, 43 and 62 years | 48/12 | Deproteinized bovine bone (Bio-Oss)
PRF+deproteinized bovine bone (Bio-Oss) |
| | Gurler G, 2016 | RCT, P | Department of Oral and Maxillofacial Surgery, İstanbul Medipol University School of Dentistry, Atatürk Bulvarı | 24 patients: age ranged from 23-66 years (mean age 47.8)
The study group: mean age of 46.3 years
The control group: mean age of 49.3 years | 10/14 | Allogenous bone + L-PRF (test)
Allogenous bone (control) |
|
|
RCT: randomized controlled trial.
SM: split-mouth.
P: prospective.
|
(b) Characteristics of the included studies |
| | First Author (Year of Publication) | Outcomes | Follow-up | PRF Preparation
technique | RBH (mm) |
| | Nizam N, 2018 | Primary outcomes: newly formed bone, residual bone graft, and newly formed bone-to-bone contact
Secondary outcomes: clinical and radiographic data (6 months after augmentation; implant survival rate 12 months after implant loading) | 12 months | A table centrifuge (Nüve Laboratory Equipment, NF200, Ankara, Turkey)
or 12 min at 400 × g | Test: 2.45 ± 0.79
Control:
2.53± 0.61 |
| | Zhang Y, 2012 | New bone formation: percentage of residual bone substitute contact length between newly formed bone and bone substitute | 6 months | PRF by Choukroun’s Procedure (300 g for 10 min) | < 5 |
| | Comert K S, 2017 | Primary outcomes: new bone formation, mean percentages of residual graft particle area, percentages of soft tissue, and no postoperative maxillary sinus infection
Secondary outcomes: mean densities of bone cells (osteoblasts, osteoclasts, osteocytes, and osteoprogenitors), capillary vessels, and inflammatory cells | Control group: 6.14±0.57
months;
P-PRP group: 6.08±0.67 months;
PRF group: 6.29±0.53 months | PRF by Choukroun’s Procedure (3000 rpm for 10 min) | < 7 |
| | Tatullo M, 2012 | New bone; complications; ISQ values (Implant Stability Quotient); bone density; clinical success rate | 150 days | Choukroun’s procedure | < 5 |
| | Gurler G, 2016 | Healing Index (HI) scores
Inflammatory and infectious reactions
Patient comfort | 14 days | Centrifuge (IntraSpin, USA)
at 2700 rpm for 12 min | NA |
|
|
RBH: residual bone height.
|
