Ginkgolide B Mediated Alleviation of Inflammatory Cascades and Altered Lipid Metabolism in HUVECs via Targeting PCSK-9 Expression and Functionality

Figure 6

Ginkgolide B reduces the affinity of PCSK-9 to complex with EGF-A-like repeats of LDL-R. (a) PCSK-9-EGF-A-complex (PCSK-9 chains have been represented as ribbon structures in various colors, while EGF-A of LDL-R has been represented as purple ribbon-like structure). (b) Ginkgolide B-PCSK-9-EGF-A-complex (Ginkgolide B has been represented in yellow as ball-stick molecule). (c) Atorvastatin-PCSK-9-EGF-A-complex (Atorvastatin has been represented in yellow as ball-stick molecule).

(a)

(b)

(c)