Dihydrochalcone Derivative Induces Breast Cancer Cell Apoptosis via Intrinsic, Extrinsic, and ER Stress Pathways but Abolishes EGFR/MAPK Pathway

<div>Alteration of cytosolic and mitochondrial Ca<sup>2+</sup> levels in MDA-MB-231 and MCF-7 cells. After treatment with compound 1 for 24 hours, cancer cells were incubated with Fluo-3AM for 15 minutes to measure cytosolic Ca<sup>2+</sup> (a). Mitochondrial Ca<sup>2+</sup> was measured in MDA-MB-231 and MCF-7 cells after being treated cells with compound 1 for 24 hours and incubated with Rhod-2AM for 15 minutes (b). The cells were analyzed by employing flow cytometry. The data are shown as mean ± SD of fluorescence intensity as folds compared to the control (without treatment) from three independent experiments. 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BioMed Research International

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Figure 5

Figure 5: Dihydrochalcone Derivative Induces Breast Cancer Cell Apoptosis via Intrinsic, Extrinsic, and ER Stress Pathways but Abolishes EGFR/MAPK Pathway 

Figure 5 | Dihydrochalcone Derivative Induces Breast Cancer Cell Apoptosis via Intrinsic, Extrinsic, and ER Stress Pathways but Abolishes EGFR/MAPK Pathway 