Dihydrochalcone Derivative Induces Breast Cancer Cell Apoptosis via Intrinsic, Extrinsic, and ER Stress Pathways but Abolishes EGFR/MAPK Pathway

<div>Caspase-3, caspase-8, and caspase-9 activities of MDA-MB-231 and MCF-7 cells after treatment with compound 1 for 24 hours. The caspase-3 (a), caspase-8 (b), and caspase-9 (c) activities were measured by using individual specific tetrapeptide substrates tagged with para-nitroaniline, and the absorbance of cleaved <i>p</i>-NA was determined by a spectrophotometric microplate reader. 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BioMed Research International

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Figure 6

Figure 6: Dihydrochalcone Derivative Induces Breast Cancer Cell Apoptosis via Intrinsic, Extrinsic, and ER Stress Pathways but Abolishes EGFR/MAPK Pathway 

Figure 6 | Dihydrochalcone Derivative Induces Breast Cancer Cell Apoptosis via Intrinsic, Extrinsic, and ER Stress Pathways but Abolishes EGFR/MAPK Pathway 