Dihydrochalcone Derivative Induces Breast Cancer Cell Apoptosis via Intrinsic, Extrinsic, and ER Stress Pathways but Abolishes EGFR/MAPK Pathway

Table 3

Inhibitory concentrations of compound 2 at 24 and 48 hours.

Cell types	Concentrations of compound 2 (μM)
	24 hours			48 hours
	IC10	IC20	IC50	IC10	IC20	IC50
MDA-MB-231	—	—	>300	14.0 ± 2.1	31.1 ± 3.4	85.9 ± 5.3
MCF-7	25.2 ± 5.6	42.9 ± 3.3	75.7 ± 0.2	15.2 ± 2.5	22.8 ± 2.5	46.2 ± 4.7

, IC₅₀ of compound 2-treated MDA-MB-231 compared with that of compound 2-treated MCF-7 at 48 hours. , IC₅₀ of compound 2-treated MCF-7 at 24 hours compared with that of compound 2-treated MCF-7 at 48 hours.