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BioMed Research International
Volume 2019, Article ID 7315714, 10 pages
https://doi.org/10.1155/2019/7315714
Research Article

Comparison of the Effectiveness of High-Intensity Interval Training in Hypoxia and Normoxia in Healthy Male Volunteers: A Pilot Study

1Department of Physiology, Academy of Physical Education in Katowice, Katowice, Poland
2School of Medicine with the Division of Dentistry, Department of Lung Disease and Tuberculosis, Medical University of Silesia, 1 Koziołka St. 41-803 Zabrze, Katowice, Poland
3Department of Neuroscience and Imaging, Dipartimento, University di Madonna delle Piane, Via dei Vestini 31, 66100 Chieti, Italy

Correspondence should be addressed to Aleksandra Żebrowska; lp.eciwotak.fwa@aksworbez.a

Received 2 June 2019; Revised 7 August 2019; Accepted 5 September 2019; Published 22 September 2019

Academic Editor: Toshiyuki Sawaguchi

Copyright © 2019 Aleksandra Żebrowska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims. The study investigated the effect of high-intensity interval training in hypoxia and normoxia on serum concentrations of proangiogenic factors, nitric oxide, and inflammatory responses in healthy male volunteers. Methods. Twelve physically active male subjects completed a high-intensity interval training (HIIT) in normoxia (NorTr) and in normobaric hypoxia (HypTr) (FiO2 = 15.2%). The effects of HIIT in hypoxia and normoxia on maximal oxygen uptake, hypoxia-inducible factor-1-alpha, vascular endothelial growth factor, nitric oxide, and cytokines were analyzed. Results. HIIT in hypoxia significantly increases maximal oxygen uptake () levels compared to pretraining levels. Serum hypoxia-inducible factor-1 () and nitric oxide levels (), vascular endothelial growth factor (), and transforming growth factor-β () levels were increased in response to exercise test after hypoxic training. There was no effect of training conditions for serum baseline angiogenic factors and cytokines () with higher HIF-1α and NO levels after hypoxic training compared to normoxic training (F = 9.1; and F = 5.7; , respectively). Conclusions. High-intensity interval training in hypoxia seems to induce beneficial adaptations to exercise mediated via a significant increase in the serum concentrations of proangiogenic factors and serum nitric oxide levels compared to the same training regimen in normoxia.