Evaluations of Biomarker Status Changes between Primary and Recurrent Tumor Tissue Samples in Breast Cancer Patients

Figure 1

Representative examples of IHC analysis of the studied biomarkers on a biopsied specimen. ER was markedly expressed (ER score 2+) and PR staining status was negative. The staining score of HER2 was 2+ (FISH test showed that the tumor was HER2-amplified). H&E, hematoxylin and eosin stain; IHC, immunohistochemistry; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; FISH, Fluorescence in situ hybridization.

(a)

(b)

(c)

(d)