Review Article

Immunological Aspects of Graves’ Ophthalmopathy

Figure 4

The participation of orbital fibroblasts in orbital inflammation. Cytokines, growth factors, and T cells stimulate orbital fibroblasts to produce chemokines and cytokines. PGE2 produced by orbital fibroblasts activates mast cells and B-cell maturation as well as stimulates the production of IL-6 by orbital fibroblasts.