Review Article
Immunological Aspects of Graves’ Ophthalmopathy
Table 1
Potential therapeutic targets in GO [
6,
103].
| Target | Treatment | Potential benefit | |
| TSHR | TSHR-blocking antibody; TSHR antagonist | Inhibition of hyaluronan production and adipogenesis | [109] | IGF-1R | Teprotumumab—IGF-1R-blocking antibody | Inhibition of hyaluronan production and adipogenesis | [87, 88] | CD3 | Teplizumab and otelixizumab—CD3 monoclonal antibodies | Induction of tolerance | [89] | CTLA4 | Abatacept—CTLA4 analogue | Increased T-cell activation | [90] | CD20 | Rituximab—CD20 monoclonal antibody | Increased TRAb production | [5, 94, 95] | TNF and TNF receptor | Adalimumab—TNF-blocking monoclonal antibody; Etanercept—soluble TNF receptor | Inhibition of hyaluronan production and inflammation | [99, 110] | TGF-β | TGF-β-blocking monoclonal antibody | Reduction in fibrosis | [111] | IL-6 receptor | Tocilizumab—IL-6 receptor monoclonal antibody | Inhibition of hyaluronan production and inflammation | [101, 112] | IL-1 receptor | Anakinra—IL-1 receptor antagonist | Inhibition of hyaluronan production and inflammation | [113] |
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