Research Article

RNA-Sequencing and Bioinformatics Analysis of Long Noncoding RNAs and mRNAs in the Prefrontal Cortex of Mice Following Repeated Social Defeat Stress

Table 5

Fourteen candidate target genes associated with psychiatric disorders and their gene annotations.

lncRNA Gene IDlncRNA SymbolmRNA Gene IDmRNA SymbolPossible gene function in psychiatric disorders

ENSMUST00000133808ENSMUSG00000087679ENSMUST00000129928Arhgef1Expressed in cortical neural progenitor cells to regulate neurite outgrowth

MERGE.17177.9MERGE.17177.9ENSMUST00000094280Chchd2Response to mitochondrial stress; its mutation is reported in patients with Parkinson’s disease

MERGE.19055.3MERGE.19055.3ENSMUST00000137133Fam107aA unique link between stress and actin dynamics, which regulates long-term potentiation and cognition performance

MERGE.23389.1MERGE.23389.1ENSMUST00000064477Dlg1A known brake on myelination in the central nervous system

MERGE.26604.5MERGE.26604.5ENSMUST00000172835Nova2Encodes NOVA2, a neuron specific RNA-binding protein, which regulates axon guidance during cortical development

MERGE.32926.1MERGE.32926.1ENSMUST00000128145Dpf1Essential for post-mitotic neural development and dendritic morphogenesis

MERGE.36317.1MERGE.36317.1ENSMUST00000135214Shank3Encodes postsynaptic scaffolding protein SHANK3, essential for hyperpolarization activated cation channels, neuronal morphology, and synaptic connectivity

MERGE.41589.1ENSMUST00000135916MERGE.41589.1Dlg4Encodes postsynaptic density 95 (PSD95), a major synaptic protein that clusters glutamate receptors and is crucial for synaptic plasticity

NONMMUT035884.2NONMMUG022075.2ENSMUST00000129928Arhgef1Same as aforementioned

NONMMUT035884.2NONMMUG022075.2ENSMUST00000056129Npas4As immediate-early gene, Npas4 affects synaptic connection between excitatory and inhibitory neurons, neural circuit plasticity, and memory formation

NONMMUT045609.2NONMMUG028155.2ENSMUST00000135214Shank3Same as aforementioned

NONMMUT055012.2NONMMUG034136.2ENSMUST00000114317Grin1Encodes NMDA receptor GluN1 subunit; its mutation is reported in patients with epileptic encephalopathy, intellectual disability, and movement disorders

NONMMUT058932.2NONMMUG036638.2ENSMUST00000126866Sez6A candidate gene in autism, bipolar disorder, intellectual disability, and childhood onset schizophrenia

NONMMUT077752.1NONMMUG048253.1ENSMUST00000168513Pick1Encodes cytosolic protein PICK1, which facilitates the removal of GluA2 subunit from the synaptic plasma membrane

NONMMUT144756.1NONMMUG091158.1ENSMUST00000185503Dnajc13Dnajc13 mutation confers a toxic gain-of-function, impairs endosomal transport, and is an etiological contributor to Parkinson’s disease

NONMMUT149941.1NONMMUG094248.1ENSMUST00000020308Ddit4Encodes DDIT4, a negative regulator of myelination during peripheral nerve system development