Delayed Rectifier K⁺-Channel Is a Novel Therapeutic Target for Interstitial Renal Fibrosis in Rats with Unilateral Ureteral Obstruction

Figure 1

Fibrotic marker expression and leukocyte proliferation in UUO rat kidneys. (a) Masson’s trichrome staining and immunohistochemistry using antibodies for collagen III (brown) and α-smooth muscle actin (α-SMA) (brown) in control (A, E, I) and UUO rat kidneys with 1 week (UUO-1w; B, F, J), 2 weeks (UUO-2w; C, G, K), and 3 weeks (UUO-3w; D, H, L) after unilateral ureteral obstruction. Magnification: ×20. (b) Hematoxylin and eosin (H&E) staining and immunohistochemistry for Ki-67 (brown) in control (A, E) and UUO rat kidneys with 1 week (UUO-1w; B, F), 2 weeks (UUO-2w; C, G), and 3 weeks (UUO-3w; D, H) after unilateral ureteral obstruction. (A–D) Magnification: ×20. (E–H) Magnification: ×60.

(a)

(b)