Cox-2 Negatively Affects the Protective Role of Propofol against Hypoxia/Reoxygenation Induced Cardiomyocytes Apoptosis through Suppressing Akt Signaling

Figure 2

Propofol inhibited the up-regulation of Cox-2 induced by H/R. (a) Relative mRNA expression of Cox-2 in H9c2 cardiomyocytes under H/R challenge with addition of propofol at different concentrations. (b) Western blot analysis of Cox-2 expression in H9c2 cardiomyocytes under H/R challenge with addition of propofol at different concentrations. NC means negative control; HR means H/R treatment group; P means treatment of propofol (in μM); D means DMSO. Data were presented as the mean ± SD (n ≥ 3). P<0.05, P<0.01, P<0.001.

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