BioMed Research International / 2019 / Article / Fig 3

Research Article

Effects of Pyrene on Human Liver HepG2 Cells: Cytotoxicity, Oxidative Stress, and Transcriptomic Changes in Xenobiotic Metabolizing Enzymes and Inflammatory Markers with Protection Trial Using Lycopene

Figure 3

Changes in mRNA expression of antioxidant enzymes and inflammatory markers in HepG2 cells exposed to pyrene. The effects of pyrene (0–50 n) on (a) HO-1, (b) GSTO1, (c) SOD1, (d) CAT, (e) TNF-α, and (f) COX2 mRNA expression as determined by real-time RT-PCR. Data are presented as mean ± SD (n = 6). Columns with different superscript letters are significantly different from each other ().
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