Effects of Pyrene on Human Liver HepG2 Cells: Cytotoxicity, Oxidative Stress, and Transcriptomic Changes in Xenobiotic Metabolizing Enzymes and Inflammatory Markers with Protection Trial Using Lycopene

Figure 4

Protective effects of lycopene against pyrene-induced adverse effects in HepG2 cells. Ameliorative effects of lycopene (0–10 μM) on pyrene- (50 n) induced (a) cytotoxicity and oxidative stress, (b) phase I enzymes, (c) phase II enzymes, (d) xenobiotic transporters, (e) antioxidant enzymes, and (f) inflammatory markers. Data are presented as mean ± SD (n = 6). Values carrying asterisks () are different at , () are different at , and () are different at , in comparison with the control.

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