Glutathione Peroxidase 1 Promotes NSCLC Resistance to Cisplatin via ROS-Induced Activation of PI3K/AKT Pathway

<div><i>GPX1 could affect the PI3K-AKT pathway in NSCLC</i>. (a) In cisplatin sensitive cell lines H460 and H1650, forced expression of GPX1 increased the level of activated AKT (detected using antibody against phosphorylated AKT) whereas downregulation of GPX1 by siRNA reduced the level of activated AKT. (b) Overexpression of GPX1 increased BCL2 level and reduced Bax expression, whereas downregulation of GPX1 inhibited BCL2 expression and increased Bax expression.</div>

BioMed Research International

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Figure 4

Figure 4: Glutathione Peroxidase 1 Promotes NSCLC Resistance to Cisplatin via ROS-Induced Activation of PI3K/AKT Pathway 