Review Article
The Level of Vitamin D in Children and Adolescents with Nonalcoholic Fatty Liver Disease: A Meta-Analysis
Table 5
Subgroup analysis of studies comparing the association between vitamin D levels and children and adolescents with NAFLD.
| | Subgroups | No. (NAFLD/Control) | Pooled SMD (95% CI) | | I2 (%) | P |
| | 25(OH)D (ng/ml) | | | | | | | Overall | 2052 (524/1528) | -0.593 (-0.983, -0.204) | P = 0.003 | 89.8% | P<0.001 | | Study type | | | | | | | Cross-sectional | 746 (203/543) | -0.793 (-1.673, 0.088) | P = 0.078 | 94.5% | P<0.001 | | Case-control | 1306 (321/985) | -0.418 (-0.674, -0.162) | P = 0.001 | 58.2% | P = 0.066 | | Geographic location | | | | | | | Western | 1559 (254/1305) | -0.856 (-1.558, -0.154) | P = 0.017 | 93.7% | P<0.001 | | Eastern | 493 (270/223) | -0.428 (-0.955, 0.098) | P = 0.111 | 87.3% | P<0.001 | | BMI (kg/m2) | | | | | | | Obese | 581 (296/285) | -0.495 (-1.160, 0.170) | P = 0.144 | 93.2% | P<0.001 | | Non-obese | 1064 (203/861) | -0.834 (-1.715, 0.046) | P = 0.063 | 89.5% | P = 0.002 | | Else | 407 (25/382) | -0.609 (-1.016, -0.202) | P = 0.003 | NR | NR | | Age (years) | | | | | | | Children | 265(167/98) | -0.575 (-1.285,0.135) | P = 0.112 | 86.4% | P = 0.001 | | Adolescents | 1787(357/1430) | -0.606 (-1.129, -0.082) | P = 0.023 | 92.6% | P<0.001 |
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Ps denotes value for heterogeneity based on Q test; P denotes value for statistical significance based on Z test. |
