Review Article
The Association between rs2292239 Polymorphism in ERBB3 Gene and Type 1 Diabetes: A Meta-Analysis
Table 1
The main features of included studies.
| | Polymorphism | Author | Year | Country | Ethnicity | Case | Control | Genotyping
methods | No. of Cases/
Controls | P
for HWE | NOS
score |
| | rs2292239 | | | | | AA (%) | AC (%) | CC (%) | AA (%) | AC (%) | CC (%) | | | | | | | Nikitin AG | 2010 | Russia | Caucasian | 19 (10.73) | 85 (48.02) | 73 (41.24) | 14 (6.83) | 94 (45.85) | 97 (47.32) | PCR-RFLP | 177/205 | 0.165 | 5 | | | Reddy MV | 2011 | USA | Caucasian | 207 (14.44) | 676 (47.14) | 551 (38.42) | 203 (10.89) | 824 (44.21) | 837 (44.90) | TaqMan | 1434/1864 | 0.993 | 7 | | | Kiani AK | 2015 | Pakistan | Caucasian | 8 (8.79) | 37 (40.66) | 46 (50.55) | 10 (10.00) | 42 (42.00) | 48 (48.00) | TaqMan | 91/100 | 0.855 | 7 | | | Awata T | 2009 | Japan | Asian | 46 (6.26) | 299 (40.68) | 390 (53.06) | 29 (4.67) | 200 (32.21) | 392 (63.12) | TaqMan | 735/621 | 0.591 | 6 | | | Sun C | 2016 | China | Asian | 38 (10.44) | 152 (41.76) | 174 (47.80) | 37 (5.15) | 252 (35.05) | 430 (59.81) | NA | 364/719 | 0.992 | 5 | | | Wang H | 2010 | USA | Caucasian | 207 (14.44) | 676 (47.14) | 551 (38.42) | 191 (10.24) | 812 (43.54) | 862 (46.22) | TaqMan | 1434/1865 | 0.991 | 6 | | | Maziarz M | 2015 | Sweden | Caucasian | 44 (15.77) | 134 (48.03) | 101 (36.20) | 23 (12.11) | 86 (45.26) | 81 (42.63) | PCR-RFLP | 279/190 | 0.981 | 6 | | | Lemos NE | 2017 | Brazil | Caucasian | 78 (18.53) | 178 (42.28) | 165 (39.19) | 64 (12.55) | 205 (40.20) | 241 (47.25) | TaqMan | 421/510 | 0.052 | 7 | | | Espino Paisan L | 2011 | Spain | Caucasian | 82 (18.89) | 225 (51.84) | 127 (29.26) | 139 (16.43) | 403 (47.64) | 304 (35.93) | TaqMan | 434/846 | 0.780 | 6 |
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HWE: Hardy–Weinberg equilibrium; PCR-RFLP: polymerase chain-reaction fragment length polymorphism; NOS: Newcastle-Ottawa Quality Assessment Scale.
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