A Comparison of Prediction of Adverse Perinatal Outcomes between Hadlock and INTERGROWTH-21st Standards at the Third Trimester
Table 1
Parameter of ultrasound scan and maternal and pregnancy characteristics variables between the groups of infants with and without adverse perinatal outcomes.
Parameter/variable
Infants without APO (n=657)
Infants with APO (n=33)
P value
Ultrasound markers in the third trimester
Gestational age < 35 weeks at last scan
47 (7.2%)
14 (42.4%)
<0.001##
INTERGROWTH-EFW (g)
2839.0 (2520.5-3088.6)
1930.0 (1210.4-2090.6)
<0.001∗∗
INTERGROWTH-EFW centile
32.1 (15.8-54.5)
1.9 (0.5-10.5)
<0.001∗∗
Hadlock-EFW (g)
2840.4 (2543.4-3099.1)
1926.8(1311.4-2137.8)
<0.001∗∗
Hadlock-EFW centile
29.0 (10.0-50.0)
3.0 (1.0-4.0)
<0.001∗∗
Maternal characteristics
Maternal age (years)
30.1 (4.1)
30.7 (3.6)
0.34∗
Nulliparous
399 (60.7%)
19 (57.6%)
0.72#
Gestational diabetes mellitus
42 (6.4%)
4 (12.1%)
0.27##
Gestational hypertension
21 (3.2%)
13 (39.4%)
<0.001##
ART conception
10 (1.5%)
5 (15.2%)
<0.001##
Perinatal outcomes
Birth weight (g)
3340 (3040-3590)
1990 (1490-2220)
<0.001∗∗
Male
302 (46.0%)
14 (42.4%)
0.14∗∗
Gestational age < 37 weeks at delivery
30 (5.0%)
16 (48.5%)
<0.001##
Cesarean delivery
268 (44.7%)
33 (100%)
<0.001∗∗
Continuous data were expressed as means ± standard deviation and categorical data as n (%). APO: adverse perinatal outcome; ART: assisted reproduction technique. ∗P value for Student’s t-test; ∗∗P value for Mann–Whitney U test; #P value for Chi-square test; ##P value for Fisher’s exact test.
