BioMed Research International

Review Article

Pulmonary Manifestations of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome: A Systematic Review

Table 2

Case reports of definite DRESS syndrome with pulmonary involvement.
ReferenceAgeSexComorbiditiesSmoking historyLung involvement (radiologically)Pulmonary symptoms present on admissionEmpirically treated for PNAOther visceral organs involvedDrugsOnset (in days)Eosinophil countsEBVHHV6TreatmentOutcome
Hase et al. [4]64MDiabetic neuropathyNAInterstitial infiltratesYes
SOB		NoLiverCarbamazepine422192NegativeNegativePrednisolone and IVIGAlive
Sawata et al. [5]51FCrohn’s diseaseNABilateral nodulesYes
SOB		NoLiverMesalazine and bactrim725292NAPositivePrednisoneAlive
Petkov et al. [6]32MEpilepsyNAInterstitial infiltrates and ARDSNo
(SOB later)		NoLiverLamotrigine71530NANAMethylprednisoloneAlive
Karakaali et al. [7]6MNoneNALobar infiltrate and pleural effusionYes
Cough		YesLiverCefotaxime and clindamycin11430NegativeNAMethylprednisoloneAlive
James et al. [8]63MHTN, spinal stenosis, and lower extremities edemaNAInterstitial infiltratesYes
Dry cough		YesHeart, kidney, and colonFurosemide701290NegativeNegativePrednisoneAlive
Shibuya et al. [9]46FSubarachnoid hemorrhage and hereditary hemorrhagic telangiectasiaNABilateral nodulesYes
Dry cough		NoLiverZonisamide41NANegativePositivePrednisoneAlive
Leão et al. [10]77FHTN and DMNALobar infiltrate and pleural effusionNo
(SOB later)		NoKidneyNitrofurantoin38500NANAPrednisoneAlive
Hassan et al. [11]73MHTN, HLD, CAD, and hyperuricemiaHeavy smokerInterstitial infiltrateYes
SOB and dry cough		YesLiver, kidney, and brainAllopurinol303408NegativeNAMethylprednisoloneAlive
Robles et al. [12]20FAcne vulgarisNAARDSNo
(SOB later)		YesLiver and kidneyDoxycycline21980NegativeNAMethylprednisoloneAlive
Naniwa et al. [13]61MMumps, pulmonary tuberculosis, and systemic sclerosisNAInterstitial infiltratesYes
SOB		NoNoneBactrim2110,032NegativeNegativeMethylprednisoloneAlive
Gómez-Zorrilla et al. [14]31MAstrocytomaNAInterstitial infiltratesYes
SOB		NoLiverLevetiracetam46NANANADexamethasoneAlive
O’Meara et al. [15]66MHemochromatosisNAInterstitial infiltratesYes
Dry cough and SOB		NoLiver, kidney, and brainVancomycin283620NegativeNAHydrocortisoneAlive
Aouam et al. [16]14MAbsence epilepsyNAInterstitial infiltratesNoNoLiverCarbamazepine and lamotrigine483450NegativeNegativeDiscontinue medication and supportive careAlive
Lee et al. [17]29FPossible pulmonary TBNALobar infiltrate and pleural effusionYes
SOB		NoLiverCelecoxib and ethambutol384477NegativePositiveMethylprednisolone and IVIGAlive
Nawaz and Wall [18]19MSpinal fractureNAPleural effusion and interstitial infiltratesYes
SOB		YesLiver and kidneyTitanium and minocycline458704NANAPrednisoneAlive
Yee et al. [19]18FHIVNALung nodulesNoYesLiverRaltegravir351300NegativeNAPrednisoneAlive
Clayton et al. [20]26MAcne vulgarisNAInterstitial infiltrate and ARDSNoYesLiver and brainMinocycline143250NANAIV corticosteroidAlive
Bruwiere et al. [21]35FEndocarditisNAARDSNoYesLiver and kidneyTeicoplanin, moxifloxacin, and ciprofloxacin9590NANAPrednisoneAlive
Wilcox et al. [22]39MDM and HLDNAARDSYes
SOB		YesKidneyVancomycin2270NANAMethylprednisoloneAlive
Roca et al. [23]22FAcne vulgarisNAARDSYes
Cough and SOB		YesLiverMinocycline25760NegativeNAHigh-dose steroidsAlive
Wang and Li [24]50MPulmonary tuberculosisNAInterstitial infiltrates and pulmonary effusionNoNoLiverIsoniazid, rifampicin, and pyrazinamide162870NANAPrednisone and IVIGAlive
Irga et al. [25]4FEpilepsyNAARDSNoNoLiver and spleenCarbamazepine4243,500NegativePositiveMethylprednisoloneAlive
M = male; F = female; HTN = hypertension; HLD = hyperlipidemia; NA = not applicable; IVIG = intravenous immunoglobulins; PNA = pneumonia; SOB = shortness of breath.