Wnt Signaling Protects against Paclitaxel-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea <i>In Vitro</i>

<div>Wnt signaling promoted SGN survival after paclitaxel-induced damage. (a) The diagram of the assay for (b) and (c). The middle-turn cochlear SGN explants from P3 WT mice were treated with 30 <i>μ</i>M paclitaxel, 30 <i>μ</i>M paclitaxel together with a Wnt agonist (10 <i>μ</i>g/ml RS-1), or 30 <i>μ</i>M paclitaxel together with a Wnt antagonist (10 <i>μ</i>M IWP-2) for 48 h. (b and c) Tuj 1 staining (green) showed that the Pac + RS-1 group had significantly more surviving SGNs than the paclitaxel-only group, while in the Pac + IWP-2 group there were significantly fewer surviving SGNs compared to the paclitaxel-only group. <span class="nowrap"><svg height="13.532pt" id="M16" style="vertical-align:-3.4295pt" version="1.1" viewbox="-0.0498162 -10.1025 50.6052 13.532" width="50.6052pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 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BioMed Research International

fig5

Figure 5

Figure 5: Wnt Signaling Protects against Paclitaxel-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea <i>In Vitro</i> 

BioMed Research International

Wnt Signaling Protects against Paclitaxel-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea In Vitro

Figure 5