Prescribing Trend of Antirheumatic Drugs in Taiwan and Risk of Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Nationwide Cohort Study

Table 2

Covariates associated with CVD with univariate analysis.

Variable	Without CVD		With CVD		Total		p-value ^1
	N	%	N	%	N	%
Total	85,531	100	6,665	100	92,196	100.00
Patients							<0.001
General	71,480	93.04	5,350	6.96	76,830	83.33
RA	14,051	91.44	1315	8.56	15,366	16.67
Gender							<0.001
Male	26,996	91.77	2,422	8.23	29,418	31.91
Female	58,535	93.24	4,243	6.76	62,778	68.09
Age (year)	48.19 ± 16.60		64.85 ± 12.43				<0.001
≦34	15,508	99.53	74	0.47	15,582	16.9
35-44	15,806	98.30	274	1.70	16,080	17.44
45-54	23,996	95.86	1036	4.14	25,032	27.15
55-64	16,076	91.15	1561	8.85	17,637	19.13
≧65	14,145	79.18	3720	20.82	17,865	19.38
HTN							<0.001
No	77,886	93.40	5,504	6.60	83,390	90.45
Yes	7,645	86.82	1,161	13.18	8,806	9.55
HPL							<0.001
No	85,220	92.80	6,611	7.20	91,831	99.6
Yes	311	85.21	54	14.79	365	0.4
MS							0.176
No	85,408	92.78	6,651	7.22	92,059	99.85
Yes	123	89.78	14	10.22	137	0.15
DM							<0.001
No	79,705	93.67	5,385	6.33	85,090	92.29
Yes	5,826	81.99	1280	18.01	7,106	7.71
CKD							<0.001
No	84,243	92.97	6,366	7.03	90,609	98.28
Yes	1,288	81.16	299	18.84	1,587	1.72

Used Chi-square test to exam the characteristics distribution.
RA, rheumatoid arthritis; HTN, hypertension; HPL, hyperlipidemia; MS, metabolic syndrome; DM, diabetes mellitus; CKD, chronic kidney disease.