Prescribing Trend of Antirheumatic Drugs in Taiwan and Risk of Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Nationwide Cohort Study

Table 3

Risk of CVD in RA patients with multivariable analysis of Cox regression analysis.

Variables	Unadjusted	95% CI	p-value	Adjusted	95% CI	p-value
	HR			HR
Patients
General (ref.)	1			1
RA	1.36	1.28-1.45	<0.001	1.31	1.23-1.39	<0.001
Gender
Male (ref.)	1			1
Female	0.83	0.79-0.87	<0.001	0.82	0.78-0.86	<0.001
Age (year)
≦34 (ref.)	1			1
35-44	3.56	2.75-4.60	<0.001	3.50	2.71-4.53	<0.001
45-54	9.11	7.20-11.54	<0.001	8.56	6.76-10.83	<0.001
55-64	20.62	16.33-26.03	<0.001	17.65	13.97-22.31	<0.001
≧65	52.41	41.64-65.97	<0.001	40.32	31.99-50.84	<0.001
HTN
No (ref.)	1			1
Yes	3.75	3.57-3.94	<0.001	1.57	1.48-1.65	<0.001
HPL
No (ref.)	1			1
Yes	2.29	2.15-2.44	<0.001	0.99	0.93-1.07	0.963
MS
No (ref.)	1			1
Yes	1.58	0.94-2.67	0.086	0.91	0.54-1.53	0.717
DM
No (ref.)	1			1
Yes	3.24	3.04-3.44	<0.001	1.47	1.38-1.57	<0.001
CKD
No (ref.)	1			1
Yes	2.93	2.61-3.29	<0.001	1.48	1.31-1.66	<0.001

RA, rheumatoid arthritis; HTN, hypertension; HPL, hyperlipidemia; MS, metabolic syndrome; DM, diabetes mellitus; CKD, chronic kidney disease.