Research Article
Prescribing Trend of Antirheumatic Drugs in Taiwan and Risk of Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Nationwide Cohort Study
Table 3
Risk of CVD in RA patients with multivariable analysis of Cox regression analysis.
| Variables | Unadjusted | 95% CI | p-value | Adjusted | 95% CI | p-value | HR | HR |
| Patients | | | | | | | General (ref.) | 1 | | | 1 | | | RA | 1.36 | 1.28-1.45 | <0.001 | 1.31 | 1.23-1.39 | <0.001 | Gender | | | | | | | Male (ref.) | 1 | | | 1 | | | Female | 0.83 | 0.79-0.87 | <0.001 | 0.82 | 0.78-0.86 | <0.001 | Age (year) | | | | | | | ≦34 (ref.) | 1 | | | 1 | | | 35-44 | 3.56 | 2.75-4.60 | <0.001 | 3.50 | 2.71-4.53 | <0.001 | 45-54 | 9.11 | 7.20-11.54 | <0.001 | 8.56 | 6.76-10.83 | <0.001 | 55-64 | 20.62 | 16.33-26.03 | <0.001 | 17.65 | 13.97-22.31 | <0.001 | ≧65 | 52.41 | 41.64-65.97 | <0.001 | 40.32 | 31.99-50.84 | <0.001 | HTN | | | | | | | No (ref.) | 1 | | | 1 | | | Yes | 3.75 | 3.57-3.94 | <0.001 | 1.57 | 1.48-1.65 | <0.001 | HPL | | | | | | | No (ref.) | 1 | | | 1 | | | Yes | 2.29 | 2.15-2.44 | <0.001 | 0.99 | 0.93-1.07 | 0.963 | MS | | | | | | | No (ref.) | 1 | | | 1 | | | Yes | 1.58 | 0.94-2.67 | 0.086 | 0.91 | 0.54-1.53 | 0.717 | DM | | | | | | | No (ref.) | 1 | | | 1 | | | Yes | 3.24 | 3.04-3.44 | <0.001 | 1.47 | 1.38-1.57 | <0.001 | CKD | | | | | | | No (ref.) | 1 | | | 1 | | | Yes | 2.93 | 2.61-3.29 | <0.001 | 1.48 | 1.31-1.66 | <0.001 |
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RA, rheumatoid arthritis; HTN, hypertension; HPL, hyperlipidemia; MS, metabolic syndrome; DM, diabetes mellitus; CKD, chronic kidney disease.
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