Prognostic Impact of Adenosine Receptor 2 (A2aR) and Programmed Cell Death Ligand 1 (PD-L1) Expression in Colorectal Cancer
Figure 1
Assessment of protein expressions of PD-L1 and A2aR by IHC staining (400x original magnification). (a) The negative expression of PD-L1 in colorectal cancer tissues. (b) The positive expression of PD-L1 in colorectal cancer tissues (the red arrow indicates the tumor cell with positive expression of PD-L1). (c) The negative expression of PD-L1 in matched adjacent nontumor tissues. (d) The positive expression of PD-L1 in matched adjacent nontumor tissues (the red arrow indicates the cell in adjacent nontumor tissues with positive expression of PD-L1). (e) The negative expression of A2aR in colorectal cancer tissues. (f) The positive expression of A2aR in colorectal cancer tissues (the red arrow indicates the tumor cell with positive expression of A2aR). (g) The negative expression of A2aR in matched adjacent nontumor tissues. (h) The positive expression of A2aR in matched adjacent nontumor tissues (the red arrow indicates the cell in adjacent nontumor tissues with positive expression of A2aR). Notes: PD-L1 is mainly expressed on the cytomembrane. The positive expression of PD-L1 was detected in 84 (41.2%) of 204 tumor specimens and in 46 (22.5%) of the 204 matched adjacent nontumor tissues. A2aR is also mainly expressed on the cytomembrane. The positive expression of A2aR was detected in 108 (52.9%) of 204 tumor specimens and in 78 (38.2%) of the 204 matched adjacent nontumor tissues.