Prognostic Impact of Adenosine Receptor 2 (A2aR) and Programmed Cell Death Ligand 1 (PD-L1) Expression in Colorectal Cancer

Table 1

Expression of PD-L1 and A2aR in colorectal cancer tissues and adjacent nontumor tissues.

Variables	cases	Positive PD-L1 expression	Negative PD-L1 expression		p-value	Positive A2aR expression	Negative A2aR expression		p-value
Tumor tissues	204	84(41.2%)	120(58.8%)	16.302	<0.001	108(52.9%)	96(47.1%)	8.893	0.003
Non-tumor tissues	204	46(22.5%)	158(77.5%)			78(38.2%)	126(61.8%)

Notes: the positive expression of PD-L1 was detected in 84 (41.2%) of 204 tumor specimens and in 46 (22.5%) of the 204 matched nontumor adjacent tissues. The expression status of PD-L1 in tumor tissues is significantly different from that in nontumor adjacent tissues (p<0.001). The positive expression of A2aR was detected in 108 (52.9%) of 204 tumor specimens and in 78 (38.2%) of the 204 matched nontumor adjacent tissues. The expression status of A2aR in tumor tissues is significantly different from that in nontumor adjacent tissues (p=0.003).