Prognostic Impact of Adenosine Receptor 2 (A2aR) and Programmed Cell Death Ligand 1 (PD-L1) Expression in Colorectal Cancer

Table 2

Correlation between clinicopathologic factors of colorectal cancer patients with the expressions of PD-L1 and A2aR in tumor tissues (p-values were calculated by χ² test.).

Characteristic	N=204	PD-L1(-)	PD-L1(+)		p-value	A2aR(-)	A2aR(+)		p-value
Age(years)				1.189	0.276			1.510	0.219
≤60	76	41	35			40	36
>60	128	79	49			56	72
Gender				0.320	0.572			0.928	0.335
Male	124	71	53			55	69
Female	80	49	31			41	39
Location				1.679	0.195			0.716	0.398
colon	132	82	50			65	67
rectum	72	38	34			31	41
Size (cm)				1.884	0.170			5.113	0.024
≤5.0	104	66	38			57	47
>5.0	100	54	46			39	61
Differentiation				2.990	0.224			1.548	0.461
Well	18	14	4			10	8
Moderate	164	94	70			78	86
Poor	22	12	10			8	14
Depth of tumor invasion				2.566	0.109			6.429	0.011
T1/T2	40	28	12			26	14
T3/T4	164	92	72			70	94
Lymph node metastasis				7.438	0.006			1.853	0.173
No	113	76	37			58	55
Yes	91	44	47			38	53
Distant metastasis				1.135	0.287			0.878	0.349
No	185	111	74			89	96
Yes	19	9	10			7	12
TNM stage				6.062	0.014			8.069	0.005
I/II	106	71	35			60	46
III/IV	98	49	49			36	62

Notes: detailed clinicopathological characteristics of the patients; correlation between clinicopathologic factors of colorectal cancer patients with the expressions of PD-L1 and A2aR in tumor tissues, respectively. The expression of PD-L1 was significantly correlated with lymph node metastasis (p=0.006) and tumor TNM stage (p=0.014). A2aR expression was significantly correlated with tumor size (p=0.024), depth of tumor invasion (p=0.011), and TNM stage (p=0.005).