Prognostic Impact of Adenosine Receptor 2 (A2aR) and Programmed Cell Death Ligand 1 (PD-L1) Expression in Colorectal Cancer
Table 4
Univariate analysis of clinicopathologic factors for overall survival (OS) in 204 colorectal cancer patients (p-value was calculated by Kaplan-Meier method and log-rank test).
Characteristic
N=204
No. of death
No. of alive
p-value
Age(years)
1.716
0.190
≤60
76
13
63
>60
128
32
96
Gender
0.254
0.614
Male
124
25
99
Female
80
20
60
Location
0.038
0.845
colon
132
29
103
rectum
72
16
56
Size (cm)
1.997
0.158
≤5.0
104
19
85
>5.0
100
26
74
Differentiation
0.828
0.661
Well
18
5
13
Moderate
164
37
127
Poor
22
3
19
Depth of tumor invasion
5.028
0.025
T1/T2
40
4
36
T3/T4
164
41
123
Lymph node metastasis
18.061
<0.001
No
113
13
100
Yes
91
32
59
Distant metastasis
140.763
<0.001
No
185
31
154
Yes
19
14
5
TNM stage
31.582
<0.001
I/II
106
8
98
III/IV
98
37
61
PD-L1
9.329
0.002
Negative
120
17
103
Positive
84
28
56
A2aR
5.735
0.017
Negative
96
14
82
Positive
108
31
77
Notes: depth of tumor invasion (p=0.025), lymph node metastasis (p<0.001), distant metastasis (p<0.001), tumor TNM stage (p<0.001), PD-L1-positive status in tumor (p=0.002), and A2aR-positive status in tumor (p=0.017) were significantly correlated to OS (p<0.05).
