Potential Diagnostic and Prognostic Biomarkers of Circular RNAs for Lung Cancer in China

Table 2

Clinical characteristics and quality evaluation of articles enrolled in the prognosis analysis.

First Author	Published Year	Country	Ethnicity	Cancer type	CircRNA type	Name of the host gene	Expression	Specimen source	No. of patients	No. of control	Cutoff value	Follow-up time (month)	Treatment	OS (HR)	OS (LL)	OS (UL)	NOS Score
Li YS	2018	China	Asian	NSCLC	hsa_circ_0016760	SNAP47	U	Tissue	45	38	mean	60	Surgery	1.91	1.119	3.259	8
Qi Y	2018	China	Asian	NSCLC	hsa_circ_0007534	DDX42	U	Tissue	56	42	mean	60	Surgery	1.969	1.177	3.293	8
Qiu MT	2018	China	Asian	LAC	circ-PRKCI	PRKCI	U	Tissue	55	34	mean	80	Surgery	2.664	1.327	5.347	8
Qin S	2018	China	Asian	NSCLC	circ-PVT1	PVT1	U	Tissue	43	47	median	60	Surgery	1.61	0.72	3.60	8
Qiu BQ	2018	China	Asian	NSCLC	circ-FGFR3	FGFR3	U	Tissue	34	29	mean	80	Surgery	1.61	0.63	4.13	9
Su CY	2018	China	Asian	NSCLC	ciRS-7	CDR1as	U	Tissue	77	51	mean	60	Surgery	1.705	1.02	2.86	9
Wang J	2018	China	Asian	NSCLC	hsa_circ_0067934	PRKCI	U	Tissue	79	80	median	60	Surgery	3.198	1.293	5.673	9
Zhang XF	2018	China	Asian	NSCLC	ciRS-7	CDR1as	U	Tissue	41	19	median	70	Surgery	6.132	2.923	7.556	8
Zou QG	2018	China	Asian	NSCLC	hsa_circ_0067934	PRKCI	U	Tissue	41	38	median	60	Surgery	2.133	1.677	3.251	8
Ding LC	2018	China	Asian	NSCLC	hsa_circ_001569	/	U	Tissue	29	27	mean	50	Surgery	2.02	0.963	4.233	9
Han JQ	2018	China	Asian	LC	circ-BANP	BANP	U	Tissue	28	31	median	60	Surgery	1.196	0.323	4.496	8
Liu W	2018	China	Asian	LC	hsa_circ_103809	/	U	Tissue	22	22	mean	80	Surgery	1.08	0.21	5.60	6
Qu DH	2018	China	Asian	NSCLC	hsa_circ_0020123	PDZD8	U	Tissue	40	40	median	60	Surgery	1.747	0.52	5.867	8
Yan B	2018	China	Asian	NSCLC	ciRS-7	CDR1as	U	Tissue	66	66	median	90	Surgery	1.575	1.016	2.440	8
Yu WJ	2018	China	Asian	NSCLC	hsa_circ_0003998	ARFGEF2	U	Tissue	32	28	mean	40	Surgery	1.82	0.76	4.38	7
Zhao FC	2018	China	Asian	LC	circ-FADS2	FADS2	U	Tissue	22	21	median	50	Surgery	3.46	1.15	10.38	7
Liu TM	2018	China	Asian	NSCLC	hsa_circ_0001649	SHPRH	D	Tissue	22	31	mean	60	Surgery	0.471	0.238	0.934	8
Yang L	2018	China	Asian	LC	hsa_circ_0046264	P4HB	D	Tissue	55	44	median	16	Surgery	0.529	0.272	1.031	9
Chen DS	2018	China	Asian	LC	hsa_circ_100395	/	D	Tissue	35	34	mean	150	Surgery	0.61	0.25	1.49	7

NSCLC, nonsmall cell lung cancer; LAC, lung adenocarcinoma; LC, lung cancer; U, upregulated expression; D, downregulated expression; OS, overall survival; HR, hazard ratio; LL, lower limit; UL, upper limit; NOS, Newcastle-Ottawa Scale.