Porous Titanium Granules in comparison with Autogenous Bone Graft in Femoral Osseous Defects: A Histomorphometric Study of Bone Regeneration and Osseointegration in Rabbits

Figure 2

Histological characterization of PTG osseointegration. In the center, the distribution of PTGs (gold-colored) within the drill hole is visible in an overview image. (a) Detail of the strong osseointegration in the cortical compartment. (b) Much weaker osseointegration in the medullary region. (c) In large areas, the PTGs showed no signs of osseointegration at all. (d) Remnants of the resorbable membrane were still detectable. (e) Newly formed bone tissue consisted mostly of woven bone (black arrowhead) compacted by parallel-fibred bone (white arrowhead). This primary bone had already been partly remodeled into secondary lamellar bone (asterisk). (f) Border of the drill hole (white arrowhead). (g) Newly formed bone tissue was laid down in the pores of the PTGs. (h) The spaces between the granules were mostly filled with fatty marrow (microphotograph of undecalcified thin‐ground section; Levai–Laczko stained; length of scale bar equals 200 μm).