Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway

Figure 5

Proposed mechanism of PA induction of insulin resistance in HepG2 cells. PA induces miR-221 overexpression. miR-221 binds PI3K to decrease PI3K and AKT expression and phosphorylation. Impairment of the PI3K/AKT pathway results in reduced GLUT4 expression and glucose consumption, which induces insulin resistance.