BioMed Research International / 2019 / Article / Tab 3

Research Article

Vitamin D Receptor Gene Polymorphisms and Autoimmune Thyroiditis: Are They Associated with Disease Occurrence and Its Features?

Table 3

Allele and genotype frequencies of VDR SNPs in AIT patients and the control group.

AIT
n=223 (%)
Healthy controls
n=130 (%)
pOR (95% CI)

rs2228570 (FokI)

Genotype

CC (FF)72 (32.29)38 (29.23)0.71 (0.84)
CT (Ff)98 (43.95)63 (48.46)
TT (ff)53 (23.77)29 (22.31)

Allele

C (F)242 (54.26)139 (53.46)0.841.03 (0.76-1.40)
T (f)204 (45.74)121 (46.54)

rs1544410 (BsmI)

Genotype

GG (bb)86 (39.09)43 (35.83)0.51 (0.31)
GA (bB)99 (45.00)52 (43.33)
AA (BB)35 (15.91)25 (20.83)

Allele

G (b)271 (61.59)138 (57.50)0.301.19 (0.86-1.63)
A (B)169 (38.41)102 (42.50)

rs7975232 (ApaI)

Genotype

CC (aa)53 (24.65)28 (22.40)0.78 (0.94)
CA (aA)112 (52.09)70 (56.00)
AA (AA)50 (23.26)27 (21.60)

Allele

C (a)218 (50.70)126 (50.40)0.941.01 (0.74-1.39)
A (A)212 (49.30)124 (49.60)

rs731236 (TaqI)

Genotype

TT (TT)79 (36.74)42 (33.60)0.63 (0.38)
TC (Tt)106 (49.30)61 (48.80)
CC (tt)30 (13.95)22 (17.60)

Allele

T (T)264 (61.40)145 (58.00)0.381.15 (0.84-1.58)
C (t)166 (38.60)105 (42.00)

rs11568820 (Cdx2)

Genotype

GG118 (71.08)91 (76.47)0.54 (0.39)
GA46 (27.71)26 (21.85)
AA2 (1.20)2 (1.68)

Allele

G282 (84.94)208 (87.39)0.411.23 (0.76-2.01)
A50 (15.06)30 (12.61)

AIT, autoimmune thyroiditis; OR, odds ratio; CI, confidence interval; χ2 test for trend.

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