Research Article
Vitamin D Receptor Gene Polymorphisms and Autoimmune Thyroiditis: Are They Associated with Disease Occurrence and Its Features?
Table 3
Allele and genotype frequencies of VDR SNPs in AIT patients and the control group.
| | AIT n=223 (%) | Healthy controls n=130 (%) | p | OR (95% CI) |
| rs2228570 (FokI) | | | | |
| Genotype | | | | |
| CC (FF) | 72 (32.29) | 38 (29.23) | 0.71 (0.84) | | CT (Ff) | 98 (43.95) | 63 (48.46) | TT (ff) | 53 (23.77) | 29 (22.31) |
| Allele | | | | |
| C (F) | 242 (54.26) | 139 (53.46) | 0.84 | 1.03 (0.76-1.40) | T (f) | 204 (45.74) | 121 (46.54) |
| rs1544410 (BsmI) | | | | |
| Genotype | | | | |
| GG (bb) | 86 (39.09) | 43 (35.83) | 0.51 (0.31) | | GA (bB) | 99 (45.00) | 52 (43.33) | AA (BB) | 35 (15.91) | 25 (20.83) |
| Allele | | | | |
| G (b) | 271 (61.59) | 138 (57.50) | 0.30 | 1.19 (0.86-1.63) | A (B) | 169 (38.41) | 102 (42.50) |
| rs7975232 (ApaI) | | | | |
| Genotype | | | | |
| CC (aa) | 53 (24.65) | 28 (22.40) | 0.78 (0.94) | | CA (aA) | 112 (52.09) | 70 (56.00) | AA (AA) | 50 (23.26) | 27 (21.60) |
| Allele | | | | |
| C (a) | 218 (50.70) | 126 (50.40) | 0.94 | 1.01 (0.74-1.39) | A (A) | 212 (49.30) | 124 (49.60) |
| rs731236 (TaqI) | | | | |
| Genotype | | | | |
| TT (TT) | 79 (36.74) | 42 (33.60) | 0.63 (0.38) | | TC (Tt) | 106 (49.30) | 61 (48.80) | CC (tt) | 30 (13.95) | 22 (17.60) |
| Allele | | | | |
| T (T) | 264 (61.40) | 145 (58.00) | 0.38 | 1.15 (0.84-1.58) | C (t) | 166 (38.60) | 105 (42.00) |
| rs11568820 (Cdx2) | | | | |
| Genotype | | | | |
| GG | 118 (71.08) | 91 (76.47) | 0.54 (0.39) | | GA | 46 (27.71) | 26 (21.85) | AA | 2 (1.20) | 2 (1.68) |
| Allele | | | | |
| G | 282 (84.94) | 208 (87.39) | 0.41 | 1.23 (0.76-2.01) | A | 50 (15.06) | 30 (12.61) |
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AIT, autoimmune thyroiditis; OR, odds ratio; CI, confidence interval; χ2 test for trend. |