Optical Coherence Tomography of Animal Models of Retinitis Pigmentosa: From Animal Studies to Clinical Applications

Figure 12

Typical ERG records when hyperreflective changes were first recognized on SD-OCT in four different genotypes. (a) An SD-OCT image of an RCS^–/– rat on P26. (b) An ERG record of an RCS^–/– rat on P28. (c) An ERG record of a wild-type RCS^+/+ rat on P24. (d) An SD-OCT image of an RHO P23H rat on P46. (e) An ERG record of an RHO P23H rat on P42. (f) An ERG record of an SD rat on P46. (g) An SD-OCT image of an RHO S334ter rat on P15. (h) An ERG record of an RHO S334ter rat on P17. (i) An ERG record of an SD rat on P22. (j) An SD-OCT image of an RPE65^–/– mouse on P32. (k) An ERG record of an RPE65^–/– mouse on P31. (l) An ERG record of a wild-type C57BL/6J mouse on P35. The stimulus condition was 3.0 cd s/m². Animals were dark-adapted for 24 h. The amplitudes of both the a- and b-waves are compared to those of wild-type mice in Table 1.

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