Optical Coherence Tomography of Animal Models of Retinitis Pigmentosa: From Animal Studies to Clinical Applications

Figure 14

Comparison of the SD-OCT, histological, and electron microscopic findings of RPE65^–/– mice. (a) An SD-OCT image of an RPE65^–/– mouse with a diffuse hyperreflective zone in the inner and outer segment layers on P170. (b) The histological appearance of an RPE65^–/– mouse on P127. (c) The electron microscopic findings of an RPE65^–/– mouse on P127. Note the short-sized photoreceptor outer segments with regularly packed discs. (d) An SD-OCT image of a wild-type C57BL/6J mouse on P72. (e) The histological appearance of a wild-type C57BL/6J mouse on P66. (f) The electron microscopic findings of a wild-type C57BL/6J on P66. Bars indicate 100 μm in (b) and (e) and 10 μm in (c) and (f), respectively.

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